Tissuetech, Inc.

Biotissue Holdings Inc.

Hua He

Scheffer Tseng

Wei Li

Ek Kia Tan

Scheffer C G Tseng

Suzhen Zhang

Ying-Tieng Zhu

Sean Tighe

Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.

Methods of modulating bone remodeling

Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (I&#x3b1;I). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

Compositions containing HC-HA/PTX3 complexes and methods of use thereof

Compositions and preparations of fetal support tissue that prevent or reduce the proliferation and epithelial-mesenchymal transition (EMT) of epithelial cells, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or reducing the proliferation, cell migration, and EMT of epithelial cells in an individual in need thereof, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or treating proliferative vitreoretinopathy in an individual in need thereof.

Compositions and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells

Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF &#x3b2; signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.

Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition

Composition and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells

Purified amniotic membrane compositions and methods of use

Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment

Amniotic membrane preparations and purified compositions and anti-inflammation methods

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Miami, FL, United States of America

Hua He