The University of Texas System

Hua Chen

Mien-Chie Hung

Dihua Yu

Sanjay K Banerjee

Emanuel Tutuc

Leonard Franklin Register, Ii

Di-hua Yu

Allan MacDonald

Ralph Wilfred Paul

Aaron Garth Loomis

Daniel Nathan Andrew LaFoc

Mein-Chie Hung

Inti Sodemann

Xuehao Mou

A device or class of devices that provides a mechanism for controlling charge current flow in transistors that employs collective magnetic effects to overcome voltage limitations associated with single-particle thermionic emission as in conventional MOSFETs. Such a device may include two or more magnetic stacks with an easy-in-plane ferromagnetic film sandwiched between oppositely magnetically oriented perpendicular magnetization anisotropy (PMA) ferromagnets. Each stack includes two non-magnetic layers separating the easy-plane ferromagnetic film from the PMA layers. Charge current flow through one of these stacks controls the current-voltage negative differential resistance characteristics of the second stack through collective magnetic interactions. This can be exploited in a variety of digital logic gates consuming less energy than conventional CMOS integrated circuits. Furthermore, the easy-in-plane magnetic films may be subdivided into regions coupled through exchange interactions and the in-plane fixed magnetic layers in the input magnetic stacks can be used in non-volatile logic and memory.

Transistor that employs collective magnetic effects thereby providing improved energy efficiency

The present invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis and metastasis. The present invention discloses functional domains of E1A responsible for the suppression of transformation, and provides mini-E1A constructs that can be used for tumor suppression. The invention also discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors.

Mini-E1A gene and gene products

The present invention relates to methods for the inhibition, of the gene product of the neu oncogene, p185 neu tyrosine kinase. Over-expression of the neu oncogene can lead to chemoresistance. The present invention discloses the functional domains of E1A responsible for the repression of neu-mediated transformation. Further the invention discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors. Mini-E1A may be used in the treatment of cancer and other disease.

Suppression of neu overexpression using a mini-E1A gene

Suppression of tumor growth by a mini-E1A gene

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Austin, TX, United States of America

Hua Chen