Eisai Company, Limited

Eisai Inc.

Eisai R&d Management Co., Ltd.

Hu Yang

James J Kowalczyk

Mark Spyvee

Shawn Schiller

Boris M Seletsky

Galina Kuznetsov

Michael D Lewis

Ana Maria Garcia

Francis Gerard Fang

Lynn D Hawkins

Ieharu Hishinuma

Sally T Ishizaka

Takeshi Nagasu

Kentaro Yoshimatsu

Silvio A Campagna

Jeffrey Rose

Eric Schwartz

Rulin Fan

Edmund M Harrington

Amy E Christuk

Xiaoning C Sheng

The present invention provides compounds having formula (I): 

Hemiasterlin derivatives and uses thereof in the treatment of cancer

The present invention provides compounds having formula (I):  and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R-R, X, X, R, Q, and n are as defined herein.

Hemiasterlin derivatives and uses thereof

The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R&#x2013;R, X, X, R, Q, and n are as defined herein.

The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.

Immunological adjuvant compounds compositions and methods of use thereof

Peptidomimetic isoprenyl transferase inhibitors R6SCHR1&prime;CHR1WCHR2YC(:X)NR3CHR5COR4 wherein R1&equals;OH, H, alkyl, amino group or R1 and R6 together form a heterocyclic ring; R1&prime;&equals;H, alkyl, aryl; R2&equals;H, alkyl, arylalkyl, heteroarylalkyl; R3&equals;H, alkyl, arylalkyl; R4&equals;OH, alkoxy, amino group; R5&equals;natural amino acid residue or D&mdash;E&mdash;F, where D is alkyl or alkenyl, E is O, S, N, or null, F is H, alkyl, aryl, carboxy amino, etc.; R6&equals;H, alkyl, acyl, etc.; W&equals;alkyl, alkenyl; X&equals;O, S, Y is M&mdash;O&mdash;P, where M is C0-6 alkyl, O is oxygen-C0-4 alkyl, P is(un)substituted C6-20 aryl are disclosed.

Inhibitors of isoprenyl transferase

Isoprenyl transferase inhibitors

Growing community of inventors

Andover, MA, United States of America

Hu Yang