Virginia Commonwealth University

Hu Yang

Kenneth Joseph Wynne

Yan Zhang

Dana E Selley

William Dewey

Olga Zolotarskaya

Shobha Ghosh

Hongliang He

Michael Lancina

Kristoffer Valerie

Juan Wang

Hamid Akbarali

The present disclosure provides pilocarpine ionic liquid analogs useful in the treatment of ophthalmological disorders such as glaucoma.

Pilocarpine ionic liquids for treatment of glaucoma

The present disclosure relates to carbohydrate-functionalized nanoparticles and methods of treating cardiovascular disease (for example, atherosclerosis).

Carbohydrate-functionalized nanoparticles and uses thereof

Provided herein are nanoparticle conjugated synthetic opioid prodrugs that target the peripheral mu opioid receptor (MOR). The prodrugs exhibit long-lived bioavailability, do not compromise the analgesic effects of opioids administered for pain relief (and in some cases can be used for pain relief), and do not induce opioid withdrawal symptoms, when their use is discontinued. Certain of the prodrugs are especially useful for the prevention and/or treatment of unwanted opioid-induced side effects such as opioid-induced constipation (OIC).

Nanoparticle conjugated synthetic opioid prodrugs and methods of their uses

A polymer is provided, comprising a subunit having the formula: wherein A, B, C, D, a, b, c, d, and p are defined herein. Compositions, methods of making, and methods of use are provided.

Clickable polyoxetane carrier for drug delivery

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Mechanicsville, VA, United States of America

Hu Yang