Taipei Medical University

Hsueh-Hsia Wu

Ko-Jiunn Liu

Neng-Yao Shih

Sy-Jye Leu

Yi-Yuan Yang

I-Jen Huang

Wen-Shyang Hsieh

Chi-Hsin Lee

Yuan-Soon Ho

Shih-Lan Hsu

Shih-Yi Huang

Yueh-Lun Lee

Yung-Luen Shih

Ching-Yu Lin

Mei-Ru Chen

The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.

[object Object]

The present invention provides a method for the treatment and/or prevention of bacterial infection caused byand other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused byfamily in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused byfamily in central nervous system and/or peripheral blood circulation in a mammal.

The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.

Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation

Growing community of inventors

Taipei, Taiwan

Hsueh-Hsia Wu