National Cheng-kung University

The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

National Chung Cheng University

Hsing-Ying Lin

Chen-Han Huang

Hsiang-Chen Chui

Yonhua Tzeng

Chih-Yi Liu

Ralph Weissleder

Lai-Kwan Chau

Hakho Lee

Wen-Hsin Hsieh

Cesar Castro

Shih-Tse Chen

Jamil Azzi

Cheng-Wen Huang

Sangmoo Jeong

Kyaw-Oo Lau

Kyaw-Oo Kyaw

Jongmin Park

Ling-Hsuan Liu

Sean Sung-Yen Juang

Hua-Hsien Liao

Target analyte detection devices include a housing having a potentiostat and a microcontroller coupled to the potentiostat. The device also includes a substrate having a plurality of electrodes on a first surface of the substrate. A first set of electrodes of the plurality of electrodes defines a first sample detection region. The substrate is removably attachable to the housing such that the first set of electrodes is coupled to the potentiostat upon attaching the substrate to the housing. The device also includes a magnet assembly couplable to a second surface of the substrate. The magnet assembly includes a magnet positioned in the magnet assembly such that a magnetic field from the magnet extends through the substrate and the first set of electrodes into an area above the first sample detection region upon coupling the magnet assembly to the substrate.

Magnetic electrochemical sensing

Disclosed is a microfluidic biosensing system including a processor, in which a Raman barcode database corresponding to at least one Raman spectrum signal is stored, a plurality of Raman barcode beads mixed with a target fluid and coupled to at least one target bioparticle in the target fluid, a microfluidic channel disposed to make the target fluid mixed with the Raman barcode beads flow therethrough, a light source disposed on the microfluidic channel, and a spectral detection device connected to the processor and disposed to correspond to the light source. The spectral detection device receives the Raman spectrum signal generated when the target bioparticle coupled with the Raman barcode bead is irradiated, and transfers the received Raman spectrum signal to the processor. The processor determines a type of the bioparticle(s) and calculates the number of bioparticle(s) by matching the Raman spectrum signal(s) to the Raman barcode database.

Microfluidic biosensing system

The invention relates to an ultraviolet laser sterilization system, comprising an ultraviolet laser module and a scanning module. The ultraviolet laser module emits an ultraviolet laser light with a wavelength ranging from 200 nm to 280 nm. The scanning module includes a plurality of reflectors for receiving the ultraviolet laser light, and a controller for controlling rotation of the reflectors to adjust an angle of emergence of the ultraviolet laser light for sterilizing a target.

Ultraviolet laser sterilization system

The present invention relates to a sensor chip for biomedical and micro-nano structured substances and a method for manufacturing the same. The sensor chip includes plural metal nanoparticles and a porous anodized aluminum oxide film. The plural metal nanoparticles are completely contained in holes of the porous anodized aluminum oxide film and located at the bottom of the holes, and an aluminum oxide layer covering the second end of the holes has a thickness of 1 nm to 300 nm. When analytes such as biomedical molecules are provided in contact with the sensor chip, a Raman signal can be detected based on the Raman spectroscopy. The structure of the sensor chip of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the sensor chip of the present invention is of great commercial value. Also, a method of manufacturing the above sensor chip is disclosed.

Sensor chip for biomedical and micro-nano structured substances and method for manufacturing the same

A photo-sensitive composite film is disclosed, which includes plural metal nano-particles and a porous anodized aluminum oxide film. The nanoparticles can be hollow or solid with unrestricted shapes of varying diameters and lengths. The plural metal nanoparticles are completely contained in holes and attached to the bottom of the holes of the anodized aluminum oxide film, and the electrical conductivity of the photo-sensitive anodized aluminum oxide film can be changed by light exposure on the metal nanoparticles from surfaces of the anodized aluminum oxide film. The structure of the photo-sensitive anodized aluminum oxide film of the present invention is uncomplicated and the manufacturing steps thereof are simple, and therefore the photo-sensitive anodized aluminum oxide film of the present invention is of great commercial value. Also, a method of manufacturing the above photo-sensitive composite film and a photo-switched device including the same are disclosed.

Photo-sensitive composite film, method of fabricating the same, and photo-switched device comprising the same

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Kaohsiung, Taiwan

Hsing-Ying Lin