Immunwork Inc.

Other

Hsing-Mao Chu

Tse-Wen Chang

Chun-Yu Lin

Chien-Jen Lin

Wei-Ting Tian

Yueh-Hsiang Yu

Ming-Yu Hsieh

Ting-Wei Chang

Li-Yun Du

Jou-Han Chen

Disclosed herein are composite polypeptide. According to various embodiments, the composite polypeptide includes a parent polypeptide and a metal binding motif capable of forming a complex with a metal cation. The composite polypeptide may be conjugated with a linker unit having a plurality of functional elements to form a multi-functional molecular construct. Alternatively, multiple composite polypeptides may be conjugated to a linker unit to form a molecular construct, or a polypeptide bundle. Linker units suitable for conjugating with the composite polypeptide having the metal binding motif are also disclosed.

Composite polypeptide having a metal binding motif and molecular construct comprising the same

The present disclosure provides various core constructs. According to embodiments of the present disclosure, the core construct can be used to configure pharmaceutical molecules. In particular, the core construct may be conjugated with a functional element via the click chemistry.

Core constructs and their uses in configuring pharmaceutical molecules

The present disclosure provides a polypeptide including an anti-fibrin antibody and a serine protease moiety of human tissue plasminogen activator. Methods for treating thrombosis in a subject in need of such treatment using such polypeptide are also disclosed.

Polypeptide for treating pathological blood clots

The present disclosure provides various molecular constructs having a plurality of fatty acids and a functional element. Methods for treating various diseases using such molecular constructs are also disclosed.

Pharmaceutical constructs with enhanced binding affinity with albumin

The present disclosure provides various linker units and molecular constructs, each of which has a targeting element and an effector element linked therewith. Methods for treating various diseases using such linker units and molecular constructs are also disclosed.

Linker units and molecular constructs comprising the same

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

Molecular constructs for treating tumors

Molecular constructs with targeting and effector moieties for treating infectious diseases

Pharmaceuticals in joint-linker configurations for treating pathological blood clots

Multi-arm linker for treating rejection reaction in transplantation

Fusion protein for treating rejection reaction in transplantation

Molecular constructs with targeting and effector moieties comprising an SCFV specific for ectodomain of transferrin-1 receptor and fingolimod

Molecular constructs with targeting and effector moieties

Peptide core-based multi-arm linkers for treating infectious diseases

Peptide core-based multi-arm linkers for treating central nervous system diseases

Growing community of inventors

Taipei, Taiwan

Hsing-Mao Chu