National Taiwan University

Ap Biosciences Inc.

Hsin-Ta Hsieh

Jeng-Horng Her

Ching-Hsuan Hsu

Jhong-Jhe You

Guo-Dung Su

Po-Lin Huang

Hung-Tsai Kan

Ting-Yi Chang

Provided are monospecific and bispecific proteins that bind specifically to OX40 and/or PD-L1. Exemplary proteins release the inhibition through PD-L1 and stimulate T cell through OX40. Exemplary polyvalent proteins comprise at least one OX40 binding site and at least one PD-L1 binding site. In certain embodiments, the binding sites may be linked through an immunoglobulin constant region. Anti-OX40 and anti-PD-L1 antibodies are also provided.

PD-L1 and OX40 binding proteins for cancer regulation

PD-L1 and OX40 binding proteins for cancer Regulation

An optical system, an optical module and a method of manufacture thereof are provided. The optical module includes a top membrane and a bottom electrode. The top membrane includes a supporting layer, a first metal layer and an isolating layer with an opening. The first metal layer is disposed on lower surface of the supporting layer. The isolating layer is disposed on lower surface of the first metal layer. The bottom electrode, disposed below the top membrane, includes a second metal layer and a plurality of pillars. The pillars are disposed on upper surface of the second metal layer and below the isolating layer, wherein some of the pillars support the isolating layer. Wherein the pillars are used for preventing the top membrane from being pulled down to touch the second metal layer through the opening when a voltage is applied between the first and the second metal layers.

Optical system, optical module and method of manufacture thereof

A method for fabricating micro-lenses and a method for fabricating micro-lenses by photolithography are provided. The method includes forming a plurality of micro-cavities in a substrate, filling lens material into each of the micro-cavities, and heating the lens material, thereby reflowing the lens material so as to form a plurality of micro-lenses in the substrate. The micro-cavities define a boundary of each of the micro-lenses formed by reflowing the lens material, thereby preventing adjacent micro-lenses from fusing together by reflowing when overheated. The process uses negative photoresist and positive photoresist as micro-cavities and lens material respectively, thereby streamlining the fabrication method and its steps.

Method for fabricating microlenses and process of single photomask pattern-based photolithography

Growing community of inventors

Taipei, Taiwan

Hsin-Ta Hsieh