Amgen Inc.

Ucb S.a.

Ucb Pharma, S.a.

Hsieng Sen Lu

William Gleason Richards

Chadwick Terence King

Thomas Charles Boone

Wenyan Shen

Shaw-Fen Sylvia Hu

Colin V Gegg

Cen Xu

Christopher J Paszty

David W Brankow

Licheng Shi

John Philip Mayer

Shinichi Hara

John A Latham

David Guenther Winkler

Frederick W Jacobsen

Steven Kiyoshi Yoshinaga

Martyn Kim Robinson

Alastair Lawson

Alistair James Henry

Hua Zhu Ke

Aaron George Winters

Chaoyang Li

Kevin Graham

Ji Li

Josette Francedillaoise Carnahan

Kelly Sue Warmington

Andy Popplewell

Josette Francoise Carnahan

Xiaolan Zhou

Taruna Arora

Qing Chen

Huiquan Han

Michael B Mann

Larry B Tsai

Mitsuru Haniu

Por-Hsiung Lai

Dennis M Fenton

Christpher Paszty

Kelly Sue Hoffmann

John O Hui

David Winkler

Christopher Paszty

Colin V Gegg Jr

Kelly Sue Hoffman

Marty Kim Robinson

Jr Colin V Gegg

John Latham

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.

DKK1 antibodies and methods of use

Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

Human CGRP receptor binding proteins

Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.

Epitopes

Myostatin antagonists, including myostatin binding antibodies, are disclosed. Also disclosed are nucleic acids encoding and cells including myostatin antagonists; methods of production; and methods of use.

Antibodies that bind myostatin, compositions and methods

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

Treatment methods using Dkk-1 antibodies

Sclerostin epitopes

Sclerostin-binding antibodies

Methods for generating F(ab')fragments from antibodies using thermolysin as well as F(ab&#x2032;)fragments and compositions comprising F(ab&#x2032;)fragments generated by the method are described.

Method for generating F(ab')2 antibody fragments

Antibodies to Dkk-1

Growing community of inventors

Westlake Village, CA, United States of America

Hsieng Sen Lu