Academia Sinica

Mycomagic Biotechnology Co., Ltd.

Hsien-Yeh Hsu

Chi-Huey Wong

Chung-Yi Wu

Alice L Yu

Eugene Fan

Wen-Bin Yang

Tung-Yi Lin

Tseng-Rong Tu

Shih-Fen Liao

Chi-Hui Liang

Peishan Lee

Chin-Chung Hung

Kuo-Feng Hua

Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=&#x2dc;35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-&#x3b1;-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.

Antibody-mediated anti-tumor activity induced by Reishi mushroom polysaccharides

The present invention relates to a method for treating a refractory or relapsed lung cancer. Particularly, the invention provides a method and a formulation of using an immunomodulatory protein derived fromin the treatment of a refractory or relapsed lung cancer.

Method for treating a refractory or relapsed lung cancer

Compositions comprisingmycelia extracts and chromatographically separated polysaccharide-enriched fractions thereof are provided. Methods for extractingmycelia are provided. Compositions for methods for their use in amelioration, prevention and treatment of sepsis, acute endotoxemia and inflammatory responses are disclosed.

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The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from

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Taipei, Taiwan

Hsien-Yeh Hsu