National Cheng-kung University

United Microelectronics Corp.

National Applied Research Laboratories

Hsien-Chang Chang

I-Fang Cheng

Cheng-Che Chung

Fu-Liang Yang

Chen-Kuei Chung

Tzu-Ying Chen

Chia-Hsin Hou

Ko-Ting Chen

Chia-Chern Chen

Wen-Horng Yang

Tsu-Yu Chu

Peng-Ting Chen

Tien-Chun Tsai

Cheng-Ting Li

Yen-Liang Cho

Chia-Cheng Tu

Zong-Zhan Wu

A microfluidic chip for collecting dielectric particles in a fluid sample to be tested includes an insulating substrate, a first interdigitated electrode, a second interdigitated electrode, and a dielectric layer. The dielectric layer is formed on the first and second interdigitated electrodes and is made from a semiconductive inorganic material having a dielectric constant of from 3.7 F/m to 80 F/m.

Microfluidic chip

A bio-chip adapted for separating and concentrating particles in a solution includes a chip body defining a receiving space therein for receiving the solution, an inner electrode disposed in the receiving space, an outer electrode unit disposed in the receiving space of the chip body and including a first outer electrode that is spaced apart from and surrounds the inner electrode, and a second outer electrode that is spaced apart from and surrounds the first outer electrode, and a power source electrically connected to the inner electrode, the first outer electrode, and the second outer electrode. A method for using the bio-chip to separating and concentrating the particles in the solution is also disclosed in the present invention.

Bio-chip and method for separating and concentrating particles using the same

A method for separating charged particles in a liquid sample is disclosed. The method includes the steps of driving the liquid sample containing a plurality of charged particles to flow, forming a non-uniform electric field in the direction relative to the flow direction of the liquid sample by two electrodes, and aggregating the charged particles under the non-uniform electric field so as to separating the charged particles from the liquid sample. When the liquid sample flows through the non-uniform electric field, it doesn't contact to the electrodes. A device and its manufacturing method for separating charged particles in a liquid sample are also disclosed. Accordingly, the charged particles can be separated from the liquid sample easily and more effectively.

Method and device for separating charged particles in liquid sample and manufacturing method of the device

A method of antibiotic susceptibility testing is disclosed, and includes the following steps: (A) providing a sample to be tested wherein the sample contains a microbe; (B) adding an antibiotic into the sample, wherein the antibiotic serves to inhibit cell wall synthesis; (C) checking the sample by dielectrophoresis and observing a shape change of the microbe; and (D) determining whether the microbe is susceptible to the antibiotic according to the shape change thereof. The present invention also discloses a method for determining a minimum inhibitory concentration of the antibiotic.

Method for antibiotic susceptibility testing and determining minimum inhibitory concentration of the antibiotic

A method of microbial identification is disclosed. The method includes the steps of assembling dielectrophoretic particles modified with specific DNA probes on a surface thereof in a continuous fluid at a predetermined location in a microchannel to form a particle assembly by a negative dielectrophoretic force and a hydrodynamic force provided by the continuous fluid, narrowing gaps between the dielectrophoretic particles of the particle assembly to enhance the electric field in the gaps between the dielectrophoretic particles, injecting a fluid containing target DNAs of a target microbe into the microchannel at a predetermined flow rate to move the target DNAs toward the particle assembly and generating a positive dielectrophoretic force by the enhanced electric field to attract the target DNAs toward the dielectrophoretic particles of the particle assembly for hybridization with the DNA probes. The present invention also discloses a method of manipulation of nanoscale biomolecules.

Microbial identification and manipulation of nanoscale biomolecules

A method scales down an integrated circuit layout structure without substantially jeopardizing electronic characteristics of devices. First, a conductive line set includes a first conductive line and a second conductive line respectively passing through a first region and a second region. Second, a sizing-down operation is performed so that the first conductive line and the second conductive line respectively have a first region scaled-down line width, a first region scaled-down space and a first region scaled-down pitch in the first region as well as selectively have a second region original line width, a second region scaled-down space and a second region scaled-down pitch in the second region. The first region scaled-down line width and the second region original line width are substantially different from each other.

Method to scale down IC layout

A semiconductor substrate having an integrated circuit die area surrounded by a scribe lane is provided. Within the integrated circuit die area, a first trench isolation region and a second trench isolation region are formed on the semiconductor substrate, wherein the first trench isolation region isolates a first active device region from a second active device region, and the second trench isolation region comprises a plurality of trench dummy features for reducing loading effect. A first gate electrode is formed on the first active device region and a second gate electrode on the second active device region. The first active device region is masked, while the second active device region and the trench dummy features are exposed. An ion implantation process is then performed to implant dopant species into the second active device region.

Growing community of inventors

Tainan, Taiwan

Hsien-Chang Chang