National Cheng-kung University

National Science Council

Hsiao-Sheng Liu

Nan-Haw Chow

Chun-Nan Lin

Shen-Jeu Won

Shorong-Shii Liou

Yi-Wen Wang

Chien-An Chu

Wen-Tsan Chang

Chung-Ta Lee

Provided is a method of accurate and sensitive characterization and prognosis of colorectal cancer in a subject. The method includes obtaining a cancer tissue from the subject and determining the expression level of a miRNA and a target gene of the miRNA. Also provided is a kit for prognosis of colorectal cancer in a subject in need thereof.

Biomarker for prognosis of colorectal cancer

The present disclosure is directed to a regulator, a pharmaceutical composition encompassing the regulator and the application thereof. The regulator modulates the expression integrins and/or EMP2, and is employed for treating integrins-associated and/or EMP2-associated diseases.

Regulator, pharmaceutical composition encompassing the regulator and application thereof

Compounds of general Formula I in which the substituents of R.sub.1 -R.sub.7 are hydrogen, hydroxy group, C.sub.1-6 alkyl group, C.sub.1-6 alkoxy group, or epoxypropoxy, but at the most, six of the substituents can simultaneously be hydrogen, methoxy group, or hydroxy group, or epoxypropoxy group for activity against hepatoma. There are also described processes for the preparation of the novel compounds and useful intermediates. Substitute benzophenones are described.

Compounds for the treatment of hepatoma

Growing community of inventors

Tainan, Taiwan

Hsiao-Sheng Liu