Hoffmann-la Roche Inc.

Takeda Chemical Industries, Inc.

Takeda Chemical Ind., Ltd.

Hsiang-Fu Kung

Susumu Honda

Hiromu Sugino

Sidney Pestka

David L Miller

An intact human immune interferon protein and a method for the extraction and purification of intact recombinant human immune interferon is disclosed. This method permits the purification to homogeneity of intact recombinant human immune interferon.

Recombinant immune interferon having an intact carboxyl terminus

An intact human immune interferon protein and a method for the extraction and purification of intact recombinant human immune interferon is disclosed. This method permits the purification to homogenity of intact recombinant human immune interferon.

Immune interferon

Immune interferon and a method for its extraction and purification

The crystallization of human leukocyte interferon is described. In a preferred embodiment crystalline recombinant human leukocyte interferon A (IFL-rA) is prepared.

Crystalline human leukocyte interferon

An active fragment of human immune interferon and a method for the extraction and purification of this protein fragment is disclosed. This method permits the purification to homogenity of the active fragment of recombinant human immune interferon.

Homogeneous immune interferon fragment

A method for the extraction of intact recombinant human immune interferon with guanidine-HCl is disclosed. This method permits the purification to homogenity of intact recombinant human immune interferon.

Growing community of inventors

Verona, NJ, United States of America

Hsiang-Fu Kung