Tsinghua University

Industrial Technology Research Institute

Hsi-Tsung Cheng

Jya-Wei Cheng

Hui-Yuan Yu

Kuo-Chun Huang

Chung-Che Liu

Yie-Zu Hu

An antimicrobial peptide has an amino terminal and/or carboxyl terminal linked with at least one artificial bulky amino acid to increase the salt resistance and protease resistance of the antimicrobial peptide. The antimicrobial peptide of the invention has a high salt resistance, a high protease resistance, and a low hemolytic activity, simultaneously.

Salt and protease-resistance of antimicrobial peptide and the manufacture thereof

The present invention is related to a high salt-resistance antibacterial peptide by increasing width of side chain of amino acids and/or increasing length of side chain of amino acids in the antibacterial peptide; and a method for increasing salt-resistance of antibacterial peptide by increasing width of side chain and/or increasing length of side chain in the antibacterial peptide.

High salt-resistance antibacterial peptide and method for producing the same

A spray type heat-exchanging unit includes a main body; a distributive refrigerant spray module located in an upper part of the main body and having an extended distributor and a refrigerant spray surface; and a plurality of heat exchange tubes provided in the main body below the distributive refrigerant spray module. A liquid refrigerant is guided into the extended distributor to drip onto the refrigerant spray surface, and then uniformly sprayed onto the heat exchange tubes. Gaseous refrigerant produced by evaporation in heat exchange in the main body is recovered via a top opening of the main body, making the mechanical refrigerating apparatus more efficient than a refrigerating apparatus adopting a flooded evaporator, and minimizing the refrigerant charge amount and material cost required by the heat-exchanging unit.

Spray type heat-exchanging unit

Enclosed is an antagonist, which includes a peptide chain represented by an amino acid sequence. The amino acid sequence has a short sequence, C-X1X2X3X4X5-N, which is situated before and neighbored to the third cysteine (Cys, C) of the N-terminus, wherein X1 is an amino acid with aromatic ring, hydrophobic property or long chain, and X2, X3, X4 and X5 are glutamine (G), serine (S), alanine (A) and proline (P) respectively. In one embodiment, X1 is phenylalanine (F). The present antagonists can be used to inhibit or treat with the diseases caused by the activated cells expressing CXCR1 and/or CXCR2 receptor, for example, the acute or chronic inflammatory reaction induced with polymorphonuclear neutrophils (PMNs) expressing CXCR1 and/or CXCR2 receptor, and angiogenesis accompanied by tumor growth inhibition.

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Hsinchu, Taiwan

Hsi-Tsung Cheng