Kbp Biosciences Co., Ltd.

Hoyin Lo

Qian Zhang

Aichen Wang

Yan Zhang

Min Zhang

The present invention relates to a compound represented by general formula (I), a method for preparing said compound, a pharmaceutical formulation containing said compound, and the use of said compound in manufacture of a medicament for treating or preventing the fibrous degeneration disease and treating the excessive proliferation disease: wherein ring A, X, R, R, R, R, R, R, R, R, R, a, b and n are defined as those in the description.

Indolinone derivative as tyrosine kinase inhibitor

The present application relates to nitrogen-containing fused ring compounds shown by general formula (I), a pharmaceutically acceptable salt thereof and a stereoisomer thereof as CRTH2 antagonist, wherein X, X, X, X, X, W, X, Y, L, L, L, A, B are as defined in the description; the present application further relates to a method for preparing the compounds, a pharmaceutical formulation and a pharmaceutical composition comprising the compounds, a use of the compounds for the manufacture of a medicament for the treatment and/or prevention of diseases related to activity of CRTH2. 

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Jinan, China

Hoyin Lo