Verrica Pharmaceuticals Inc.

Howard Welgus

Jayson Michael Rieger

Matthew Gene Davidson

Eugene R Scavola

Paul Daly

Applicator devices (), kits, systems, and methods of using such devices for treating one or more body surface conditions (e.g., warts, Molluscum contagiosum, conjunctivitis, otitis) are provided. The applicator device facilitates topical administration of a controllable amount of a pharmaceutical composition to a desired area of an affected body surface (e.g., skin, eye, ear, nose, mouth, anus, vagina). The applicator device includes an ampule () containing the pharmaceutical composition, the ampule being positioned within a tube (). Squeezing the tube breaks the ampule, releasing the pharmaceutical composition. The applicator device includes a filter () that permits passage of fluid and inhibits passage of broken ampule shards. The applicator device includes a dispensing tip () through which the pharmaceutical composition passes.

Devices and methods for the treatment of body surface disorders

Methods of treating one or more skin lesions using cantharidin as well as associated compositions, treatment regimens, kits, devices, and systems are provided. A method of treating a subject having one or more skin lesions may involve administering a composition comprising cantharidin to one or more skin lesions. The method may allow for the efficacious treatment of the skin lesion(s) with minimal or no adverse side effects (e.g., severe adverse side effects, permanent damage of the dermal tissue, scarring, excessive blistering of skin surrounding the lesion, elevated plasma cantharidin concentration, systemic exposure to cantharidin). The efficacy and/or safety of the treatment may be due, to certain features of the composition and/or prolonged exposure of the skin lesion(s) to cantharidin. The methods described herein may be used for a wide variety of cutaneous disorders, including skin disorders that primarily affect the epidermis of skin.

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West Chester, PA, United States of America

Howard Welgus