Wyeth

Bioventus, LLC

Etex Corporation

Mathys Ag Bettlach

Genetics Institute, Inc.

Fidia Advanced Biopolymers S.r.l.

Howard Seeherman

Christopher G Wilson

John Martin Wozney

Christopher Todd Brown

Eric Vanderploeg

Rebecca Li

Marc Bohner

Robert Vincent Martinez

Stephen Berasi

Valerie Calabro

Hyun Kim

Noemie Van Garderen

Michael John Cain

Zong Sean Juo

Lanfranco Callegaro

Aliassghar N Tofighi

Alessandra Pavesio

John A Kambouris

Alex DeGasparo

Alex De Gasparo

Debra D Pittman

Brian M Clancy

Z Sean Juo

Cheryl Lee

Chase Davis

Noémie Van Garderen

Vanderploeg Eric

Christopher Brown

John Kambouris

Eric J Vanderploeg

Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.

Porous carrier matrix

Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Systems and methods for improved delivery of osteoinductive molecules in bone repair

The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing POions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally POions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of POions present in the first and second incubation is at least as large as the amount of SOions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.

Method for producing porous calcium deficient hydroxyapatite granules

The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.

Designer osteogenic proteins

The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing POions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of POions present in the incubation of step a) is at least as large as the amount of SOions of the granules used for step (a). The porous calcium deficient hydroxyapatite granules obtained by the invention may be purposefully used as carriers for biologically active substances in particular for proteins.

Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.

Matrix for enhanced delivery of osteoinductive molecules in bone repair

Osteogenic proteins

Porous calcium deficient hydroxyapatite granules

Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed.

Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins

Growing community of inventors

Cambridge, MA, United States of America

Howard Seeherman