Cold Spring Harbor Laboratory

Depymed, Inc.

Howard Sard

Jodi Blake Courtney

Nicholas K Tonks

Navasona Krishnan

Andreas Grill

Daniel J Cline

Christopher Spedaliere

Nicholas Tonks

Salvatore J Salamone

Vishnumurthy Hedge

Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

Method and compositions for forming a copper-containing complex and uses thereof

Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I:  wherein R is &#x2014;OH or &#x2014;O&#x2014;CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

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Woburn, MA, United States of America

Howard Sard