Research Development Foundation

Howard R. Six

Nathalie Garcon

Howard R Six

Brian E Gilbert

Samuel Z Wilson

Jack V Knight

Philip R Wyde

Nathalie B Garcon

The antibody response to a target antigen may be enhanced by incorporating the antigen into a liposome along with an additional constituent which contains at least one T-helper lymphocyte recognition site. The liposomes can include a wide variety of lipid materials. Both the antigen and the T-helper lymphocite recognition site containing constituent may be associated with the liposome by using hydrophobic interactions or by covalent attachment to a lipid.

Liposomes that provide thymic dependent help to weak vaccine antigens

Disclosed are aqueous aerosol droplets containing liposome or interacted liposome-drug or medication combination particles in a continuous phase of air or oxygen-enriched air advantageous for the treatment of a wide variety of diseases. The drug or medication is interacted with the liposome membrane so that on its rupture the drug or medication is not lost from the liposome. Different methods of preparation of the aerosol particles containing the liposome and interacted liposome-drug combination particles are described which can be used in small particle aerosol treatment. The majority of the aerosol droplets containing the liposome particles alone or with drugs has a diameter less than 5 microns and has an aerodynamic mass median diameter ranging from about 1 to 3 microns, and the liposome and interacted-liposome drug particles are substantially uniform in size and less than 1 micron in diameter.

Small particle aerosol liposome and liposome-drug combinations for

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East Stroudsborg, PA, United States of America

Howard R Six