Medtronic Ardian Luxembourg S.a.r.l.

Chf Solutions, Inc.

Ardian, Inc.

Plc Medical Systems, Inc.

Respicardia, Inc.

Reprieve Cardiovascular, Inc.

Cardio Technologies, Inc.

Columbia University

Gambro Uf Solutions, Inc.

Medtronic Ireland Manufacturing Unlimited Company

Intellicardia, Inc.

Nephros Inc.

Zoll Respicardia, Inc.

Medtronic Adrian Luxembourg S.a.r.l.

G & L Consulting, LLC

Howard R Levin

Mark Gelfand

Hanson Gifford

Denise Marie Zarins

Mark E Deem

Douglas Sutton

Erik Thai

Nicolas Zadno

Benjamin J Clark

Denise M Demarais

Andrew Victor Halpert

John J O'Mahony

Steven J Bernard

Hans-Dietrich Polaschegg

Paul C Michelman

Andrew H Wu

William J Allen

Gerald M Lemole

Mehmet C Oz

Juan P Umana

Alan Lotvin

Jeffrey Testani

Joshua E Tsitlik

Robert W Reinhardt

Naum Ziselson

Jim Dillon

Robert I Rudko

Mark Tauscher

Steve Bernard

Hanson S Gifford, Iii

Donald W Landry

Douglas S Sutton

Antonis Panteleon

R Mitchell Baldwin, Ii

Evan Stuart Garfein

Michael A Guttman

William A Easterbrook, Iii

Zoar Engelman

Willaim A Easterbrook, Iii

Mark S Howansky

Craig W Sherman

David C Lundmark

John O'Mahoney

Andy Halpert

Denise Demarals

Ludmila Gudis

John c/o Chf Solutions Inc O'MAHONY

Steve J Bernard

Charles D Emery

Denis Zarins

Hanson Iii Gifford

Mark Deem

Denise Demarais

A method to treat patients suffering from fluid overload including: administrating a diuretic to the patient to increase urine output of the patient; monitoring intravascular volume of the patient; and maintaining the patient in a condition in which the intravascular volume is below a baseline intravascular volume and above a hemodynamic level by adjusting the administered diuretic.

Method and system to monitor urine output and manage fluid retention in a patient

A apparatus and method to treat patients with acute decompensated heart failure (ADHF), heart failure or another fluid overload condition, that includes: administrating a diuretic to the patient to increase urine output of the patient; monitoring a rate or amount of urine output by the patient after administration of the diuretic; infusing a hydration liquid into the patient to induce an increase in the urine output; and adjusting the rate or amount of the hydration liquid infused into the patient to achieve a target fluid loss in the patient.

Method and system to treat acute decompensated heart failure

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Bilateral renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Methods and apparatus for renal neuromodulation

Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.

Managing fluid levels in a patient and associated devices, systems, and methods

An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.

System and method to modulate phrenic nerve to prevent sleep apnea

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Methods and apparatus for bilateral renal neuromodulation

Detection and treatment of disordered breathing is disclosed, with treatment being primarily delivered using electrical stimulation of the diaphragm, either directly or by stimulating appropriate nerves.

Detecting and treating disordered breathing

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

Methods for renal neuromodulation via neuromodulatory agents

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.

Methods and apparatus for monopolar renal neuromodulation

Methods for treating a hypertensive human patient are disclosed herein. A method in accordance with one embodiment comprises delivering a neuromodulatory agent to a renal nerve of the patient via an intravascularly positioned drug delivery catheter. The method includes at least partially blocking neural activity along the renal nerve with the neuromodulatory agent, which results in a therapeutically beneficial reduction in blood pressure of the patient.

Methods and devices for renal nerve blocking

Growing community of inventors

Teaneck, NJ, United States of America

Howard R Levin