Duke University

North Carolina State University

Howard Levinson

Kam W Leong

James Brian Davis

Don Ward

William J Brown

Adam P Wax

Thomas James Matthews

Jon P Rust

Jon Rust

Manuel Medina

Elizabeth R Lorden

Kyle J Miller

An implantable breast tissue mesh for use in reconstructing breast tissue includes a mesh body having a surrounding edge and at least two mesh extensions extending from the surrounding edge of the mesh body, each mesh extension comprised of mesh having a first end, a second end, and a length therebetween, the first end being integrated into or part of the mesh body. Each mesh extension is configured to be passed through surrounding tissue multiple times to create multiple anchor points with the surrounding tissue upon implantation so as to resist high tension across a breast tissue reconstruction site without dehiscing or migrating.

Implantable mesh and method of use

A warp knitted fabric formed by a warp knitting machine includes a first knitted portion formed using a first knitting sequence in a machine direction, the first knitted portion formed of a set of continuous textile strands, and a second knitted portion formed of the set of continuous textile strands using a second knitting sequence in the machine direction, the second knitted portion comprising at least two strips extending lengthwise in the machine direction and detached from one another along their lengthwise edges. The first knitted portion and the second knitted portion alternate sequentially in the machine direction. The second knitting sequence differs from the first knitting sequence in that at least one cross connecting stitch is dropped to form the at least two strips.

Warp knit fabric for textile and medical applications and methods of manufacturing the same

A method of using at least one implantable mesh extension for repairing a tissue defect or reconstructing tissue, wherein the mesh extension is comprised of a mesh having a width and a length extending between a first end and a second end, includes passing the first end of the mesh extension through tissue adjacent to the tissue defect or tissue to be reconstructed at least once and then passing the first end of the mesh extension through a portion of the mesh. The mesh extension is then pulled to create a first self-locking stitch to anchor the mesh extension to the adjacent tissue so as to immediately resist high tension.

A method of using an implantable mesh for repairing a tissue defect or reconstructing tissue, wherein the implantable mesh has a mesh body and at least two mesh extensions comprised of mesh extending therefrom, includes positioning the mesh body of the implantable mesh such that the mesh body extends across the tissue defect or tissue to be reconstructed and passing at least one mesh extension through tissue adjacent to the tissue defect or tissue to be reconstructed so as to anchor the implantable mesh to the tissue and resist high tension without dehiscing or migrating from the tissue defect or tissue to be reconstructed.

An implantable mesh for use in high tension tissue reconstruction includes a mesh body having a surrounding edge and at least two mesh extensions comprised of mesh and extending from the surrounding edge of the mesh body. Each mesh extension has a first end, a second end, and a length therebetween, the first end being integrated into or part of the mesh body. Each mesh extension is configured to be passed through tissue surrounding a reconstruction site to create multiple anchor points with the surrounding tissue upon implantation so as to resist high tension across the reconstruction site without dehiscing or migrating.

A warp knitted fabric formed by a warp knitting machine includes a first knitted portion formed using a first knitting sequence in a machine direction and a formed using a second knitted portion formed using a second knitting sequence in the machine direction, the second knitted portion comprising at least two strips extending in the machine direction, the at least two strips being detached from one another along their lengthwise edges. The second knitted portion has the same width as the first knitted portion, and the first knitted portion and the second knitted portion alternate sequentially in the machine direction and are formed of a single set of continuous textile strands.

An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the first end of the mesh extension is integrated into or part of the mesh body. Each mesh extension is configured to permit multiple anchor points with surrounding tissue upon implantation. In one embodiment, a fixation device is at the second end of each mesh extension. Methods of using the implantable mesh are also provided.

Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an illumination beam, an interferometer, and a spectrometer. The interferometer includes a first beam splitter configured to split the illumination beam into an incident beam and a reference beam; an optical lens directs the incident beam onto a biological sample at a predefined offset from corresponding optical axis, and receive a beam scattered from the biological sample. The beams are configured to intersect with each other within a focal zone of the optical lens. Photons of the incident beam undergo multiple forward scattering within the biological sample. A second beam splitter configured to receive and superimpose the scattered and reference beams, to generate an interference beam. The spectrometer uses a spectral domain detection technique to assess tissue properties of the biological sample.

Growing community of inventors

Durham, NC, United States of America

Howard Levinson