Usv Pharmaceutical Corporation

Merck & Company, Inc.

Rorer Pharmaceutical Corporation

Bristol-myers Squibb Compnay

Bristol-myers Company

Howard Jones

John T Suh

Tsung-Ying Shen

Bernard Loev

Conrad P Dorn

Wan-Kit Chan

Raymond D Youssefyeh

John J Piwinski

Jerry W Skiles

Paul R Menard

Fu-chih Huang

Edward S Neiss

Dennis M Mulvey

David Penman Jacobus

Alison B Lukacsko

Morris Zimmerman

John H Musser

James R Shroff

Robert L Clark

Ernest Magnien

Robert A Frankshun

Joseph Migliardi

Stephen M Coutts

Mujahid L Shaikh

Bruce E Witzel

Richard E Brown

Shu S Yang

Norman P Jensen

Bruce O Linn

Thomas M Tencza

David Stevenson

Laurence L Ho

Robert C Liu

Michael W Fordice

Beth A Sarsfield

Mahesh K Patel

Fu-chin Huang

Clara Lin

Robert W Houser

Richard B Greenwald

A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of ibuprofen and hydrochlorothiazide.

Pharmaceutical methods for relief of dysmenorrhea and/or premenstrual

A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of ibuprofen and hydrochlorothiazide, and, optionally, an antihistamine.

Pharmaceutical compositions for relief of dysmenorrhea and/or

A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of aspirin or ibuprofen and a diuretic from the group pamabrom and hydrochlorothiazide; optionally it may also contain an antihistamine.

Provided are antihypertensive compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different,

Antihypertensive amide compounds

This invention relates to new chemical compounds having valuable pharmaceutical activity. It particularly relates to stereoisomeric compounds possessing hypotensive activity, i.e., angiotensin converting enzyme inhibitory (ACEI) activity and having the structure ##STR1## wherein R and R.sub.9 are independently hydroxy, lower alkoxy, lower alkenoxy, di(lower alkyl)amino-lower alkoxy, hydroxy-lower alkoxy, acylamino-lower alkoxy, acryloxy-lower alkoxy, aryloxy, aryloxyl-lower alkoxy, amino, lower alkylamino, di-lower alkylamino, hydroxyamino, or aryl-lower alkylamino;

N-substituted-amido-amino acids

Compounds of the formula ##STR1## wherein R and R.sub.9 are independently hydroxy or lower alkoxy,

This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.

Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the

Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

Benzothiadiazole compounds for treating hypertension

Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful

This invention relates to new compounds of the formula ##STR1## wherein A is a hydroxy, lower alkoxy, lower alkenoxy, diloweralkylamino lower alkoxy, acylamino lower alkoxy, acyloxy, lower alkoxy, aryloxy, arloweralkyloxy, amino, loweralkylamino, diloweralkylamino, aryloweralkylamino, hydroxyamino, or substituted aryloxy, or substituted arloweralkoxy wherein the substituent is methyl, halo or methoxy; R.sub.1, R.sub.2, and R.sub.3 are each hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused aryl-cycloalkyl, aralkyl, cycloalkyl, heterocyclic, substituted alkyl, alkenyl, or alkynyl groups in which the substituents are hydroxy, alkoxy, halo, amino, aminoalkyl, alkylamino, mercapto, or alkylmercapto, substituted cycloalkyl groups in which the substituents are alkyl, halo, haloalkyl, hydroxy, alkylamino, nitro or trifluoromethyl, and substituted aryl and heterocyclic groups in which the substituents are alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, mercapto, alkylmercapto, mercaptoalkyl, haloalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, or trifluoromethyl; X is hydrogen, alkyl, alkenyl or alkynyl of up to about 20 carbon atoms, aryl or aryl lower alkyl containing from about 7 to about 12 carbon atoms, heterocyclic or heterocyclic lower alkyl cycloalkyl or cycloalkylalkyl containing up to about 20 carbon atoms, or of the formula: ##STR2## wherein n=2, 3 or 4;

N-carboxy anhydride intermediates

Compounds of the formula: ##STR1## wherein, R is H, alkyl, cycloalkyl, aryl or heteroaryl;

Bisbenzothiazine, bisbenzodiazine and bisquinoline pharmaceutical

Compounds for treating hypertension

Compounds of the general formula ##STR1## and their pharmaceutically-acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity.

1,2,3,4-Tetrahydrophthalazine and hexahydropyridazine compounds for

Antihypertensive compounds

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Holmdel, NJ, United States of America

Howard Jones