World Medical Manufacturing Corporation

Other

Abbott Cardiovascular Systems, Inc.

Medtronic Vascular, Inc.

Bioheart, Inc.

Medtronic Ave, Inc.

World Medical Corporation

Howard J Leonhardt

Syde A Taheri

Trevor Greenan

Robert D Lashinski

Juan Carlos Chachques

A catheter-based deployment system for deploying cellular material () into the heart muscle (). The deployment system includes a guiding catheter () and a needle assembly () capable of sliding within the guiding catheter. The needle assembly () terminates in a tip () having at least one side with an opening () in communication with a lumen () disposed within the needle assembly (). Once the guiding catheter () is positioned, the needle assembly () is advanced until the tip () penetrates the muscle wall (). At a predetermined depth the cellular material () may be deployed into the muscle wall () via a push rod () disposed through the lumen of the needle assembly ().

Deployment system for myocardial cellular material

The present invention relates to an apparatus for deploying an endoluminal prosthesis for engrafting a blood vessel. The apparatus includes a bifurcated graft that is able to conform to the interior surface of the blood vessel and can be deployed through a single entry site.

Apparatus for engrafting a blood vessel

A catheter-based deployment system for deploying cellular material () into the heart muscle (). The deployment system includes a guiding catheter () and a needle assembly () capable of sliding within the guiding catheter. The needle assembly () terminates in a tip () having at least one side with an opening () in communication with a lumen () disposed within the needle assembly (). Once the guiding catheter () is positioned the needle assembly () is advanced until the tip () penetrates the muscle wall (). At a predetermined depth the cellular material () may be deployed into the muscle wall () via a push rod () disposed through the lumen of the needle assembly ().

The present invention provides a method for enhancing regeneration of the myocardium. The method comprises the steps of applying electrical stimulation to an injury site in the myocardium. The method can be used in combination with implantation of myogenic cells into the injury site. The electrical stimulation may be applied before or after the implantation.

Method of enhancing myogenesis by electrical stimulation

The present invention provides a method for repairing damaged myocardium. The method comprises using a combination of cellular cardiomyoplasty and electrostimulation for myogenic predifferentiation of stem cells and to synchronize the contractions of the transplanted cells with the cardiac cells. The method comprises the steps of obtaining stem or myogenic cells from a donor, culturing and electrostimulating the isolated cells in vitro, and implanting the cells into the damaged myocardium.

Method of providing a dynamic cellular cardiac support

A method for deploying an endoluminal prosthesis by introducing into a bifurcated vessel a sheath introducer having therein a bifurcated graft with a primary and contralateral limb. The contralateral limb being radially retained independent of the sheath introducer. The graft being positionable by an insertion catheter. When the graft is in position within the vessel, a retaining device about the contralateral limb is broken and the graft takes the shape of the vessel.

Method for engrafting a blood vessel

The present invention relates to an apparatus for deploying and endoluminal prosthesis. The apparatus includes a flexible compressible push rod that allows the catheter to be easily maneuvered through tortuous vessels while providing sufficient deployment force.

A biological pacemaker and implantation catheter for restoring normal or near normal heartbeat function without a mechanical pacemaker. The biological pacemaker is provided by a bridge of implantation cells, such as nerve cells, stem cells or ganglion cells, that are introduced into an area of electrical malfunction, such as an impaired SA node or a blocked AV node. The implantation cells grow to form a conductive cell bridge around the malfunction area so that a new pathway is provided for the electrical signals responsible for triggering heart beat contractions. The implantation catheter has a central nerve cell injection needle connected to a syringe or the like via a cell injection tube, and two elongated lateral stabilizing needles. The catheter is inserted into a blood vessel in a patient's leg, arm, shoulder or the like, and advanced until the catheter's distal end is located above the malfunction area. The distal end of the catheter is bent so that the three needles are facing the malfunction area. The two stabilizing needles are advanced into the heart wall to stabilize the catheter and the nerve cell injection needle is advanced for injection of the implantation cells.

Biological pacemaker and implantation catheter

A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the ingrowth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.

Delivery system for development and endovascular assembly of a multi-stage stented graft

A method of autogenous cell patch cardio myoplasty using noninvasive thoracoscopy is disclosed. A patient's greater omentum is separated from its point of attachment to either the greater curvature of the stomach or the transverse colon. All open blood vessels in the greater omentum are ligated to permanently arrest bleeding. The greater omentum is introduced into the left pleural cavity through an opening in the diaphragm. Muscle grafts are removed from skeletal muscle tissue of the patient and an opening is formed in the pericardium to expose an area of damaged myocardium. Following attachment of the skeletal muscle grafts to either the greater omentum or the damaged myocardium area, preferably using an advanced muscle graft implantation system, the greater omentum is wrapped around the heart and attached thereto in order to reinforce the muscle grafts and enrich them with blood flow from the greater omentum.

Autogenous cell patch cardio myoplasty and advanced muscle graft implantation system

A thin-walled prosthesis is provided that includes a tubular graft formed of a monofilament fiber. The graft has sufficient strength and durability to withstand loads applied during deployment and while implanted and sufficiently low permeability to prevent excessive leakage of body fluids through the material or to provide a sufficient seal, for example, so as to prevent aneurysm pressurization. A preferred embodiment of the present invention relates to a tubular grafts constructed of monofilament fibers for endoluminal placement within a body lumens, including blood vessels, and for the treatment of abdominal and other aneurysms.

Tubular graft with monofilament fibers

An apparatus and method for engrafting a blood vessel are disclosed. The apparatus includes a tubular graft having radially compressible annular spring portions for biasing proximal and distal ends of the graft into conforming fixed engagement with an interior surface of the vessel, with bifurcated and adjustable length embodiments being disclosed. Apparatus for deploying the graft includes an insertion catheter having a nitinol core wire, a controllable tip balloon-at a remote end thereof for dilation and occlusion of the vessel, and a controllable graft balloon in the vicinity of the tip balloon for fixedly seating the spring portions into conformance with the interior surface of the vessel. A spool apparatus for adjusting or removing an improperly placed graft, and a micro-emboli filter tube, are usable with the deployment apparatus. A method of percutaneously implanting a graft, including a single-entry method for percutaneously implanting a bifurcated graft, are also disclosed.

Endoluminal prosthesis

A multi-stage stent graft for implantation into a blood vessel is disclosed. Each stage or layer may comprise radially compressible spring stents with or without a fabric covering, or may comprise a foamed tube. The various stages or layers may also have an adhesive coated thereon. The multi-stage stented graft and the adhesive coatings provide a surface for the in growth of cells and promote healing. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stented graft during one trip into the vasculature.

Delivery system for deployment and endovascular assembly of a multi-stage stented graft

A radiation delivery catheter with inflatable chambers which provide a layer of radiation of minimum effective dose possible to be delivered as close as possible to the origin of disease within a blood vessel. The device can be centered within the true lumen of a vessel to provide even dispersion of the radiation agent to the outer wall of the vessel. The catheter comprises two central self centering balloons, one thin radiation agent inflatable chamber, and one radiation spread cloaking inflatable chamber with high strength properties resistant to rupture.

Growing community of inventors

Weston, FL, United States of America

Howard J Leonhardt