Delsys Pharmaceutical Corporation

Sarnoff Corporation

Other

David Sarnoff Research Center, Inc.

Howard Christopher Rivenburg

Bawa Singh

Nitin Vithalbhai Desai

Pabitra Datta

Peter John Zanzucchi

Eugene Samuel Poliniak

William Ronald Roach

David A Keller

Hoi Cheong Sun

Peter David Southgate

Dominic Stephen Rosati

Nalin Kumar

Lawrence Harrison Hammer

Aaron W Levine

Hoi Cheong Steve Sun

Michael R Arneson

Timothy Allen Pletcher

James Regis Matey

Robert Richard Demers

Suggy S Chrai

Ramaswamy Murari

Bogdan Brycki

Hoi Cheong (Steve) Sun

Prince Lal

Edward F Divers, Iii

Paul Bilhuber

William Yat Chung Chiang

Dominic S Rosati

Nitin Vithabhi Desai

Methods using dry powder deposition apparatuses

In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon, at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.

Inhaler apparatus with modified surfaces for enhanced release of dry powders

A spraying device for dispensing electrostatic liquid droplets includes a container holding a liquid at one end, and having a nozzle assembly with an aperture at another end. The nozzle assembly includes a longitudinal hollow tube terminating in a metallic structure. The metallic structure includes a metallic base plate having at least one aperture formed therein for fluid communication with the hollow tube. The longitudinal hollow tube includes an end inserted in the liquid. A charge accumulator disposed in the liquid accumulates electrostatic charges. A wire conductor between the base plate and the charge accumulator transfers the electrostatic charges from the liquid to the nozzle assembly.

Spraying device for dispensing home care formulations with electrostatic liquid droplets

A substrate is roboticaly picked up at a station and transported to a measuring station to measure the distance to a reference. The substrate is aligned to a robot before measurement. The measured substrate is then transported to a pharmaceutical or diagnostic powder/grain deposition station where the powder/grains are controllably deposited on the substrate to predetermined thicknesses over a plurality of powder/grain collection zones. The deposited powder/grains are then measured to determine the thickness and area covered by the deposited powder/grains at each collection zone. The substrate is then transported to a lamination station and each collection zone of powder/grains is welded to a cover substrate. The system remembers which collection zones are out of specification so that they can be later selectively discarded.

Pharmaceutical product

Provided is a method of moving a charged particle from a first position at which it is retained by a first electrode to a second position at which it is retained by a second electrode, the method comprising: applying a potential to the second electrode to attract the particle; and applying a potential to a guide electrode offset from the particle at the first position, wherein the applied potential is effective to reduce the attraction of the particle to the first position sufficiently to allow the potential applied at the second electrode to be effective to move the particle from the first position to the second position.

Bead or particle manipulating chucks

Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising:

Dry powder deposition apparatus

In one aspect, the present invention provides an inhaler apparatus comprising interior surfaces having contact with a medicament for inhalation, the interior surfaces including an interior surface of a mouthpiece and a substrate with medicament deposited thereon at least one of such interior surfaces comprising indentations or raised areas therein, the raised areas having valleys therebetween. In certain preferred embodiments, the interior surface is a surface on a substrate having medicament deposited thereon, and in other preferred embodiments, the interior surface is an interior surface of the mouthpiece of the inhaler. In addition to providing surface topology for minimizing the area of contact between the medicament and the surfaces of the inhaler, the surfaces are preferably made of a material having a low surface energy, and more preferably, also having, when uncharged, no substantial van der Waals or electrostatic interaction with the medicament. Furthermore, the material is preferably substantially chemically unreactive with the medicament.

Inhaler apparatus with modified surfaces for enhanced release of dry

The present invention is directed, in part, to an inhaler apparatus with a substrate having medicament deposited thereon, the substrate being configured for electronic release of the medicament. In preferred embodiments, the inhaler comprises a conductive layer and a dielectric layer thereon. In preferred embodiments, the inhaler further comprises a second conductive layer positioned above the substrate without having contact with the substrate. In certain preferred embodiments, the voltage source is connected to the conductive layer in the substrate and the second conductive layer above the substrate. In other preferred embodiments, the inhaler apparatus further comprises a third conductive layer positioned below the substrate, and the voltage source is preferably connected to the second conductive layer above the substrate and the third conductive layer below the substrate In another aspect, the present invention provides a method for dispensing a medicant from an inhaler, comprising: (a) providing an inhaler with a substrate having a medicant deposited thereon, the substrate comprising a conductive layer and a dielectric layer and a voltage source connected to said conductive layer; and (b) actuating the voltage source.

Inhaler apparatus with an electronic means for enhanced release of dry

The present invention provides an acoustic dispenser for propelling objects toward a substrate, together with methods of use of the dispenser. The acoustic dispenser uses a source of acoustic vibration and a membrane for the application of acoustic vibration wherein the objects are propelled from the membrane to a substrate. The acoustic dispenser and the methods of the invention can be used with numerous types of objects. In some embodiments, the objects are particles in a dry powder, which can include, for example, a pharmaceutically active ingredient. In other embodiments, the objects are beads, which preferably have an average diameter of about 100 to about 300 microns. Additionally, the acoustic dispenser can be used with more than one type of object, for example, two types of objects such as beads and dry powder. In some instances, the acoustic dispenser further comprises a membrane for separating one type of object from the other based on size, whereby one type of object is separated from the other prior to deposition.

Acoustic dispenser

A power source comprises at least one photovoltaic cell arranged adjacent a plurality of self-luminous microspheres containing a radioactive material such as tritium and phosphor particles. Photons generated from the phosphor particles strike the photovoltaic array which converts the light to electrical energy. The self-luminous microspheres can be arranged adjacent the photovoltaic array using a binder material. The inventive power source provides a portable, safe, and long lasting battery which is adaptable for a wide range of applications requiring a reliable power source.

Power source using a photovoltaic array and self-luminous microspheres

Growing community of inventors

Princeton, NJ, United States of America

Howard Christopher Rivenburg