Allertein Therapeutics, LLC

Other

University of Arkansas

Mount Sinai School of Medicine

Panacea Pharmaceuticals, Inc.

N-fold LLC

Feil Golf, LLC

Howard B Sosin

Michael J Caplan

Hugh A Sampson

A Wesley Burks, Jr

H Kim Bottomly

Tarek Fahmy

Clifford Sosin

Michael Caplan

The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.

Nanoparticle compositions

The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity.

Microbial delivery system

The present invention provides methods and compositions for treating or preventing allergic reactions, particularly anaphylactic reactions. Methods of the present invention involve administering microorganisms to allergic subjects, where the microorganisms contain a recombinant version of the protein allergen. The recombinant version can be wild-type or may include mutations within IgE epitopes of the protein allergen. Preferably the compositions are administered rectally. Particularly preferred microorganisms are bacteria such as. Any allergen may be used in the inventive methods. Particularly preferred allergens are anaphylactic allergens including protein allergens found in foods, venoms, drugs and latex. The inventive compositions and methods are demonstrated in the treatment of peanut-induced anaphylaxis.

Methods and reagents for decreasing clinical reaction to allergy

A method and device for marking golf balls that allows for the placement of a putting directional indicator (PDI) along the dynamic axis of a ball. While golfers could use the device to mark individual balls after they have been purchased (i.e. after they already have marks on them from the manufacturer), in preferred embodiments, the PDI is applied at the manufacturing stage and/or before the ball has other markings placed upon it. While the PDI could simply consist of one or more lines, in a preferred embodiment, the putting directional indicator may serve as an identifying mark for a manufacturer, distributor or consumer and may be designed to incorporate letters, words, symbols, short sentences, names, initials, numbers, images and photographs.

Method and device for marking golf balls

A method and apparatus is disclosed that allows a user to individually or simultaneously customize the pitch, roll, height, yaw, linear placement and lateral placement of his/her boots on his/her skis. This system allows the user to stand in a position while skiing that is closer to his/her natural position and to have the parameters of such a stance measured and quantified, thereby improving comfort, performance, and safety. As opposed to the limited variation in only some parameters described by current art, this invention allows significant variation in all individual parameters and simultaneous customization of all parameters. This simultaneity is important because of its increased ease to the skier and because altering any one parameter can change the center of pressure, thus creating the need for additional changes until the perfect combination of adjustments is made. In particular, the system allows for the alteration of the yaw of the ski boot alone or in combination with any or all of the other parameters.

Method and apparatus for the customization of boot placement on skis

A block putter, usable with either a conventional or sidesaddle putting stance for a right-handed or left-handed golfer, having a head width in the range of about one half to about twice the width of a golf ball. The increased width and potentially increased weight of the putter head improve its performance both on the green and when hitting from the fringe, the fairway, or the rough, or out of the sand. The golfer may use the toe of the putter, rather than one of the faces, to strike the ball, for increased accuracy, especially on short putts. Alternatively, the golfer may putt in a sidesaddle stance with the traditional putter face using a putter having an elongated shaft. The elongated shaft is of such a length as to allow for the end of the shaft to rest on the golfer's shoulder and help stabilize the putt.

Block putter

Compositions are administered to block IgE binding to receptors and ultimately displace native IgE from mast cells and related cell types, to prevent the activation of these cells during an allergic response. The compositions consist of a pharmaceutically acceptable carrier for systemic or local administration and an amount of compound binding specifically to the Fc&egr;RI IgE binding sites, and more preferably, Fc&egr;RI and Fc&egr;RII IgE binding sites, to prevent activation and degranulation of mast cells in response to exposure to allergens. The compounds can consist of IgE molecules and fragments and modifications thereof, such as IgE fragments, humanized or single chain IgE antibodies or fragments thereof, IgE with a modified Fab, non-crosslinkable IgE, or peptidomimetics which bind to the same site on the receptor as the IgE, jointly referred to herein as &ldquo;IgE fragments&rdquo; unless otherwise stated.

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Fairfield, CT, United States of America

Howard B Sosin