The Upjohn Co.

Howard A Whaley

John H Coats

Barney J Magerlein

William C Snyder

John C Greenfield

Fritz Reusser

Alexander D Argoudelis

Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.

Antibiotic nodusmicins

Antibiotic nodusmicin derivatives

Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.

Biologically pure culture of Streptomyces microspinus NRRL 12524 capable

Composition of matter and process

Esters of antibiotic nodusmicin

Novel antibiotic U-61,732 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against gram-positive bacteria, for example, Staphylococcus aureus. Also disclosed are the 11-acyl esters of U-61,732. Thus, these compounds can be used in various environments to eradicate or control such bacteria.

Antibiotic composition of matter

A process for preparing the antibiotic U-59,760. The process is a microbiological process using a biologically pure culture of the novel microbe Saccharopolyspora hirsuta strain 367, NRRL 12045. The antibiotic produced by the process is active against various microorganisms, for example, Staphylococcus aureus, Streptococcus pyogenes, and Klebsiella pneumoniae. Thus, antibiotic U-59,760 can be used in various environments to eradicate or control such bacteria.

Saccharopolyspora culture

Process for producing antibiotic using saccharopolyspora

Novel antibiotic U-59,761 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against various microorganisms, for example, Staphylococcus aureus, Streptococcus pyogenes, Sarcina lutea, Klebsiella pneumoniae, Mycobacterium avium, and Bacteroides fragilis. Thus, antibiotic U-59,761 can be used in various environments to eradicate or control such bacteria.

Antibiotic and fermentation process of preparing

New antibiotic U-47,929 produced by the controlled fermentation of the new microorganism Streptomyces ficellus Dietz, sp. n., NRRL 8067. This antibiotic and its acid-addition salts are active against Gram-positive bacteria. Accordingly, they can be used in various environments to eradicate or control such bacteria.

Growing community of inventors

Portage, MI, United States of America

Howard A Whaley