Debiopharm S.a.

Houssam Ibrahim

Rolland-Yves Mauvernay

Henri Pourrat

Christine Deuschel

Philippe Genne

Martine Bayssas

The present invention relates to an oxaliplatin active substance for a pharmaceutical composition, wherein its weight content in oxalic acid is not more than 0.08%, and to a process of preparing the active substance.

Oxaliplatin active substance with a very low content of oxalic acid

The invention concerns a pharmaceutically stable oxaliplatinum preparation for parenteral administration, the oxaliplatinum being in a precipitate-free, colorless and clear solution after being preserved for a pharmaceutical acceptable duration. In said preparation, the oxaliplatinum is contained in a solution in a solvent at a concentration of at least 7 mg/ml and the solvent comprises a sufficient amount of at least a hydroxylated derivative selected among 1,2-propane-diol, glycerol, maltitol, saccharose and inositol. The invention also concerns a method for preparing said solution.

Pharmaceutically stable oxaliplatinum preparation for parenteral administration

The present invention relates to a stable pharmaceutical preparation of oxaliplatin for parenteral administration, in which the oxaliplatin is in solution in a solvent at a concentration of at least 7 mg/ml, which has been subjected to an operation of wet heat treatment with steam in the saturation state and under pressure at a high temperature not exceeding 110&#xb0; C. It also relates to the method for the production thereof.

Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same

The invention relates to pharmaceutical compositions containing cinchonine dihydrochloride as active ingredient with a purity of at least 95%. The invention also relates to a process for preparing cinchonine dihydrochloride from cinchonine and the use of pharmaceutical compositions containing cinchonine dihydrochloride for treating multiple drug resistance.

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Veyrier, Switzerland

Houssam Ibrahim