Doheny Eye Institute

University of Southern California

Other

California Institute of Technology

Hossein Ameri

Mark Salman Humayun

James David Weiland

Stefan Ufer

Helmut Eckhard

Yu-Chong Tai

Damien Craig Rodger

Armand R Tanguay, Jr

K Kirk Shung

Qifa Zhou

Wen Li

Amani Fawzi

Gerald Chader

Tenapat Ratanapakorn

Tanapat Ratanapakorn

Xiaochen Xu

The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways. The vibration effect of the ultrasound itself may suffice to dislodge clots. The microbubbles may also be coated or filled with medication, with ultrasonic shock waves activating the coating or causing mini explosions to release the medicine. Loading the microbubbles with a therapeutic agent, visualizing their presence at the diseased site using the ultrasound diagnostic mode, and then activating the microbubbles to release their contents at the targeted lesion could be a powerful and effective way to reverse occlusion without harming other areas of the eye or body.

Ultrasound and microbubbles in ocular diagnostics and therapies

Systems and methods are disclosed providing for the use of ultrasound energy to measure blood flow within blood vessels by Doppler velocity measurement. Directional high-frequency pulsed-wave Doppler measurements can be made with a suitable ultrasonic needle transducers for in vivo measuring of blood flow. A needle probe can include a ultrasonic material such as PMN-PT. Such blood flow measurements can be made in any part of the body, e.g., in the central retinal vein and branch retinal veins.

Intraocular ultrasound doppler techniques

Embodiments of the present disclosure are directed to utilization of one or more arrays that are placed under the choroid. In this approach, an array is placed under the choroid. To achieve this, a scleral incision can be made without cutting the underlying choroid or retina. The array can then be inserted into the space between the sclera and choroid and is pushed to the desired place. It is possible to make several of such scleral incisions in each quadrant of the eye to insert arrays of similar or different shapes into the subchoroidal space. Following insertion of the electrode array the scleral wound may be sutured around the cable to make the array and the eye more stable.

Subchoroidal retinal prosthesis

A wide-filed retinal prosthesis enables an increased field of vision with a relatively small scleral incision. The retinal prosthesis includes a flexible substrate comprising a central member and at least one wing, with an array of electrodes disposed therein that are configured to stimulate the central and peripheral nerves of the retina.

Wide-field retinal prosthesis

Intraocular retinal prosthesis devices and methods for fabricating the same. A prosthesis device includes a cable region that connects an electrode array region with a power and data management region. The electrode array region includes one or more arrays of exposed electrodes, and the power and data management region includes various power and control elements. The power and data management elements, in one aspect, include an RF coil or coils and circuit arrangements and/or chips configured to provide drive signals to the electrodes via a cable and receive power and signals from the RF coil or coils. Each region includes elements fabricated on or in a single polymer layer during the same fabrication process.

Method of fabricating an integrated intraocular retinal prosthesis device

A universal frame for providing a hands free, stable base for ophthalmic measurements comprising a first adjustable ear piece and a second adjustable ear piece, and a measuring instrument detachably connected with the universal frame for exopthalmos and enopthalmos measurements.

Apparatus and method for ophthalmometery

Growing community of inventors

Alhambra, CA, United States of America

Hossein Ameri