King Abdulaziz University

Hossam Samir El-Sawy

Tarek Abdelnapy Ahmed

Khalid Mohamed El-Say

Omar D Al-hejaili

Fathy I Abd-Allah

A buccal tablet formulation has a polyvinylpyrrolidone K-90 as a solid dispersion polymer, a hydroxypropyl methylcellulose as a mucoadhesive polymer, a sodium deoxycholate as mucopenetration enhancer, a porous silicon dioxide (e.g., FujiSil), mannitol, and avanafil. The ratio of PVP K-90 to AVA is approximately 2:1 (e.g., 2.3:1 to 1.7:1) in the tablet. Methods of making the buccal tablet with enhanced bioavailability and prolonged duration and methods of using the formulation for the treatment of erectile dysfunction are also provided.

Buccal formulation of avanafil with enhanced bioavailability and prolonged duration

A transdermal film composition including a film forming polymer comprising poly(ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride) 1:2:0.2, oleic acid, polyethylene glycol, and atorvastatin calcium. Methods of making the composition and administering the composition to deliver atorvastatin to a subject are also provided.

Growing community of inventors

Jeddah, Saudi Arabia

Hossam Samir El-Sawy