Transmedics, Inc.

Hossam Algamil

Waleed H Hassanein

Tamer I Khayal

Richard Bringham

Giovanni Cecere

Ronald Taylor

Scott W Newell

Dmitri Menn

Ronald L Taylor, Jr

Stanley Kyi

Robert Fishman

Burt Ochs

Robert Havner

Larry Goff

David M Carpenter

Jonathan M Rourke

Ahmed Elbetanony

Paul Lezberg

Dennis Sousa

Lawrence Goff

John Rourke

Thomas H Bishop

Tamer Khayal

Waleed Hassanein

Scott Newell

David Carpenter

The invention provides, in various embodiments, a method comprising placing an ex-vivo heart in a chamber of an organ care system; connecting the ex-vivo heart to a perfusion fluid circuit of the organ care system; starting a pump configured to provide, via the perfusion fluid circuit, a perfusion fluid to the ex-vivo heart; synchronizing at least one maximum output of the pump with an r-wave of the ex-vivo heart; testing the ex-vivo heart or the organ care system; adjusting a setting of the organ care system in response to a result of the testing; and after adjusting the setting of the organ care system in response to the result of the testing, re-testing the ex-vivo heart or the organ care system.

Systems and methods for ex-vivo organ care

The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near physiologic conditions. In certain embodiments, the disclosure relates to testing properties of an ex-vivo heart or an organ care system, adjusting a property of the organ care system in response to certain results of the testing, and re-testing the ex-vivo heart or the organ care system. In certain embodiments, the disclosure relates to synchronizing at least one cycle of a pumping of a perfusion fluid with a state of the ex-vivo heart.

An organ care system including a blood product heater that includes a heater inlet, a channel, and a heater outlet, wherein the heater inlet includes an inside cross-sectional area and an inside cross-sectional shape configured to flow a blood product into the blood product heater, wherein the heater outlet comprises an inside cross-sectional area and an inside cross-sectional shape configured to flow the blood product out of the blood product heater, and wherein the channel extends between the heater inlet and the heater outlet and is formed between a first flow channel plate and a second flow channel plate; and a first heater thermally coupled to the first flow channel plate configured to heat the first flow channel plate; and a pump configured to circulate a heated blood product to an organ being preserved.

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

Method of timing pulsatile flow of normothermic perfusate to the heart

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Scranton, PA, United States of America

Hossam Algamil