Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Centrum Fur Angewandte Nanotechnologie (Can) Gmbh

Topas Therapeutics Gmbh

Daimler Chrysler Ag

Universitaetsklinikum Hamburg-Eppendorf

Förderung Der Angewandten Forschung E.v.

Centrum Fuer Angewandte Nanotechnologie (Can) Gmbh

Universitatsklinikum Hamburg-Eppendorf

Horst Weller

Theo Schotten

Markus Haase

Johannes Herkel

Oliver T Bruns

Christoph Hahn

Carsten Ott

Johannes Ostermann

Jan Steffen Niehaus

Jörg Heeren

Peter Nielsen

Ansgar Lohse

Sunhild Salmen

Werner Scherber

Thomas Kraenzler

Hans-Ulrich Moritz

Barbara Freund

Marieke Dieckmann

Antonella Carambia

Stefan Lüth

Katja Werner

Stephan Haubold

Fernando Ibarra

Daniel Ness

Jochen Haering

Jan Niehaus

Christian Schmidtke

Alexander Fischer

Jan-Philip Merkl

Michaela Steuter

Joerg Heeren

Ulf Zum Felde

Karsten Riwotzki

Werner Pauer

Heike Meyssamy

Andreas Kornowski

Tim Strupeit

Christian Fuhrmann

Steffen Jan Niehaus

Van Huong Schmidtke-Tran

Hauke Kloust

Sascha Kappen

Elmar Pöselt

The present invention relates to a zwitterionic nanoparticle, the zwitterionic nanoparticle comprising at least one nanoparticle and a zwitterionic case enclosing the nanoparticle. Furthermore, the present invention relates to a composition, a method of binding a zwitterionic nanoparticle and the use of a zwitterionic nanoparticle.

Zwitterionic nanoparticles

The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.

Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions

The present invention relates to a composition, comprising at least one micelle in non-aqueous solution, wherein the micelle encapsules one or more nanoparticle(s) and wherein the micelle comprises a cross-linked hydrophilic shell. Furthermore, the present invention relates to the use of such a composition and to methods for providing such a composition.

Polymer micelles containing nanoparticles in non-aqueous solution, methods for their preparation and use

The present invention relates to a composition, comprising at least one micelle in non-aqueous solution, wherein the micelle encapsules one or more nanoparticles. Furthermore, the present invention relates to the use of such a composition and to methods for providing such a composition.

The present invention relates to a process for the continuous preparation of core-shell nanoparticles, comprising a core of a core material, preferably of a semiconductor material, and a shell of a shell material, preferably of a semiconductor material, wherein selected starting materials for the shell material are mixed with a dispersion of nanoparticles of the core material and are passed continuously through a reaction zone of a tubular reactor, and other starting materials for the shell material are fed to the reaction zone of the tubular reactor at two or more locations, preferably via a tubular membrane, and the starting materials for the shell material react in the reaction zone to form a shell around the nanoparticles of the core material. The invention also relates to the tubular reactor with the membrane and its use for the continuous synthesis of core-shell nanoparticles. The invention also relates to core-shell nanoparticles comprising a core of a core material, preferably of a first semiconductor material, and an outer shell of a shell material, characterized in that, between core and shell, there is only a layer of a transition zone, in which the proportion of the core material gradually decreases toward the shell, while the proportion of the shell material gradually increases.

Method for producing core/shell nanoparticles and core/shell nanoparticles

An apparatus () and a method () for the manufacture of nanoparticles. The apparatus and the method allows for the nucleation and growth of nanoparticles at independent temperatures. The independent temperatures allow for the growth of nanoparticles in a controlled environment avoiding spontaneous nucleation and allowing particle sizes to be controlled and facilitating the manufacture of particles of a substantially uniform size. Furthermore the apparatus () allows for the manufacture of core-shell nanoparticles and core-shell-shell nanoparticles.

Reactor for the manufacture of nanoparticles

A method for the manufacture of a III-V compound in the form of nanoparticles, such as those used in semi-conductors. The reaction proceeds at atmospheric pressure in a reaction solution by the reaction of a III compound source and a V compound source. The reaction proceeds in solvent of high boiling point. The solvent contains a stabilizer and a base. The manufactured III-V compound is precipitated from the reaction solution, isolated, purified and analyzed.

III-V nanoparticles and method for their manufacture

Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.

Synthesis of nanoparticles

Electrochromic element

Growing community of inventors

Hamburg, Germany

Horst Weller