Molecular Devices Corporation

Ecole Polytechnique Federale De Lausanne

Other

Newcastle University Ventures Limited

Horst Vogel

Michael Pawlak

Christian Schmidt

Jeremy Hugh Lakey

Thorsten Wohland

Holger Lang

Rudolf H A Rigler

Bernd Koenig

Evelyne Schmid-Osborne

Axel K Preuss

Ana-Paula Tairi

Horst M Pick

The invention provides a product comprising: a membrane-spanning protein; a lipid membrane formed from amphiphilic molecules and membrane-spanning protein molecules; and a substrate, wherein the membrane protein is directly coupled to the substrate. The invention also provides a method for producing such a product which i) comprises treating a substrate with a hydrophilic coating agent; ii) providing at least one membrane-spanning protein; iii) bringing the protein into contact with the treated substrate under conditions for the coupling of the protein directly to the treated substrate; and iv) adding amphiphilic molecules to the protein-coupled substrate to form a lipid membrane. The product is useful for biosensors, protein arrays and the like.

Biosensor

Systems for positioning and/or analyzing samples such as cells, vesicles, cellular organelles, and fragments, derivatives, and mixtures thereof, for electrical and/or optical analysis, especially relating to the presence and/or activity of ion channels.

Sample positioning and analysis system

Multiaperture sample positioning and analysis system

The invention concerns an assembly comprising: (a) means for determining the intensity of a plurality of electromagnetic signals, (b) a correlator for correlating or autocorrelating said signals, (c) means for continuously calculating the variance and/or the standard deviation of said signals. It also concerns a method for analysing the intensity of a plurality of electromagnetic radiations scattered and/or emitted from solid, fluid or gaseous samples.

Assembly and method for a correlator structure

The invention relates to a measuring device which permits a very simple positioning of cells and vesicles respective of cell membranes on planar carriers. The invention also relates to a corresponding highly efficient method for the positioning and electric characterization of such membranes with a consistently high signal-to-noise ratio. In addition, statements concerning interactions of substances with lipid membranes respective of materials bonded thereon or therein respective of signal transduction mechanisms connected thereto are possible.

Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers

Lipid membrane sensors

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Preverenges, Switzerland

Horst Vogel