Behringwerke Aktiengesellschaft

Aventis Behring Gmbh

Horst Naumann

Norbert Heimburger

Hubert Metzner

Hermann Erich Karges

Hans M Preis

Helmut Heber

Hermann Pelzer

Joerg Lemmer

The invention relates to a method for hydrogen peroxide plasma sterilization, wherein the chamber temperature is set at less than 39&deg; C. throughout, and containers with temperature-sensitive products can be efficiently sterilized without the temperature-sensitive products showing a significant loss of activity or degradation.

Use of a hydrogen peroxide plasma sterilization method for the mild sterilization of temperature-sensitive products

The invention relates to a process for producing a virus free preparation of thrombin, and the use of said virus free concentrate as a pharmaceutical. For example, the invention relates to a process for the production of a purified and virus free preparation of thrombin which comprises adding a soluble salt in a concentration of from 0.5 mol/l up to the saturation limit thereof, said soluble salt having an anion that forms a sparingly-soluble salt or a soluble complex with calcium, to a solution of a prothrombin complex which has been purified on an anion exchanger and subjected to virus inactivation, said solution having a catalytic amount of thrombin present as a result of the purification, the viral inactivation, or added thereafter at a concentration of greater than zero up to 200 units of thrombin per ml of solution.

Process for the production of a virus-free concentrate of thrombin

The invention relates to a process for the preparation of C1 inactivator, which, if appropriate, is hepatitis-free and, if appropriate, can be lyophilized, and its use as a medicament.

Process for the preparation of the C1 inactivator

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Marburg, Germany

Horst Naumann