Bayer Aktiengesellschaft

Farbenfabriken Bayer Aktiengesellschaft

Horst Meyer

Friedrich Bossert

Wulf Vater

Kurt Stoepel

Egbert Wehinger

Stanislav Kazda

Robertson Towart

Gerhard Franckowiak

Arend Heise

Bernward Garthoff

Matthias Schramm

Axel Ingendoh

Andreas Knorr

Rainer Gross

Gunter Thomas

Martin Bechem

Michael Kayser

Siegfried Goldmann

Jurgen Stoltefuss

Ulrich Rosentreter

Horst Boshagen

Eckhard Schwenner

Ulrich Benz

Freidrich Bossert

Elisabeth Perzborn

Bodo Junge

Harald Horstmann

Friedel Seuter

Eike Moller

Siegbert Hebisch

Rudi Grutzmann

Rudiger Sitt

Friedrich Hoffmeister

Mithat Mardin

Klaus Schlossmann

Ekkehard Niemers

Gunther Thomas

Wolf-Dieter Busse

Stanislav Kaada

Benward Garthoff

Stanislay Kazda

Friedrich Bosseret

The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.

Optically active 1,4-dihydropyridine esters useful for treating

Novel circulation-active cyclohexenecarboxylates of the formula ##STR1## in which R.sup.1 is an organic radical,

Circulation-active cyclohexenecarboxylates

A composition effective for treating circulation disorders comprises a mixture of ##STR1## wherein the variables can have varied meetings. I are inotropic and II are vasodilating but, whereas the ingredients in the combination would be expected to be antagonistic, they are reinforcing.

Mixture of different dihydropyridines

Circulation active tetrahydropyridines of the formula ##STR1## in which R.sup.1 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 20 carbon atoms and can be interrupted in the chain by an oxygen atom or a sulphur atom and/or can be substituted by halogen, cyano, hydroxyl, acyloxy, nitro or nitrooxy, or by a phenyl, phenoxy, phenylthio or phenylsulphonyl group which is optionally substituted by halogen, cyano, dialkylamino with in each case 1 or 2 carbon atoms per alkyl group, alkoxy with 1 to 4 carbon atoms, alkyl with 1 to 4 carbon atoms, trifluoromethyl or nitro, or by an .alpha.-, .beta.- or .gamma.-pyridyl group, or by an amino group, this amino group carrying 2 identical or different substituents from the group comprising alkyl with up to 4 carbon atoms, alkoxyalkyl with up to 4 carbon atoms, phenyl and aralkyl, and these substitutents optionally forming, with the nitrogen atom, a 5- to 7-membered ring which can contain, as a further hetero atom, an oxygen or sulphur atom or an N-phenyl or N-alkyl grouping, this alkyl group containing 1 to 3 carbon atoms,

Circulation-active tetrahydropyridine-3-carbonitrile derivatives

The compound,

Hypotensive long-acting 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclic,

Coronary-active fluorine-containing 1,4-dihydropyridines

Circulation-active dihydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,

Circulation-active 1,4-dihydropyridine derivatives and use thereas

An alkenecarboxylic acid of the formula ##STR1## in which R.sup.1 denotes hydrogen, aryl, substituted aryl or a straight-chain or cyclic, saturated or unsaturated aliphatic hydrocarbon radical, which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl, and which is optionally substituted by hydroxyl, alkoxy, alkyl, trifluoromethyl, halogen, phenyl, alkoxycarbonyl or dialkylamino, the two alkyl radicals together with the nitrogen atom optionally forming a 5 to 7-membered ring, which optionally contains a heteroatom from the group comprising O, S, NH or N-alkyl and these aforementioned alkyl and phenyl radicals in turn optionally being substituted by halogen, trifluoromethyl, alkyl, aryl, aralkyl, alkoxy, alkylmercapto or SO.sub.2 -alkyl,

Imidazothiadiazolealkylene carboxylic acids

1,4-Dihyropyridinecarboxamides of the formula ##STR1## and salts thereof, are effective for treating cardiac insufficiency, thromboses, thromboembolisms and ischaemias, for influencing the blood-sugar level and the circulation and as coronary therapeutic agents and anti-arrhythmic agents.

Circulation active dihydropyridine-3-carboxamides

Pyridinecarboxylic acid esters of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,

Ischaemia or hypoxia controlling compositions containing

A carbonyl compound of the formula ##STR1## in which R.sup.1 denotes hydrogen, aryl, substituted aryl or a straight-chain or cyclic, saturated or unsaturated aliphatic hydrocarbon radical, which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl, and which is optionally substituted by hydroxyl, alkoxy, alkyl, trifluoromethyl, halogen, phenyl, alkoxycarbonyl or dialkylamino, the two alkyl radicals together with the nitrogen atom optionally forming a 5 to 7-membered ring, which optionally contains a heteroatom from the group comprising O, S, NH or N-alkyl and these aforementioned alkyl and phenyl radicals in turn optionally being substituted by halogen, trifluoromethyl, alkyl, aryl, aralkyl, alkoxy, alkylmercapto or SO.sub.2 -alkyl,

Amidazothiodiazone carbonyl compounds useful to prepare novel

##STR1## in which optically pure products are obtained. The process is novel, as is II. I is known as being active on the blood circulation system.

Intermediates of optically active 1,4-dihydropyridines

Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R.sup.1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl and which is optionally substituted,

Novel hypotensive imidazothiadiazolealkanecarboxamides

The present invention refers to novel anellated 4H-1,4-benzothiazines, several processes for the synthesis thereof, their use as pharmaceutical agents, in particular their use as lipoxygenase-inhibiting agents, pharmaceutical compositions containing the novel benzothiazines and a process for their manufacture.

Anti-thrombotic pharmaceutical compositions comprising

Compounds of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,

Asymmetric diesters of Hantzsch dihydropyridines with hypotensive

Growing community of inventors

Wuppertal, Germany

Horst Meyer