Basf Aktiengesellschaft

Horst Koenig

Josef Gries

Marco Thyes

Hans D Lehmann

Dieter Lenke

Albrecht Franke

Phillip A Rossy

Walter Boell

Fritz-Frieder Frickel

Ludwig Friedrich

Hans-Joachim May

Herbert Naarmann

Hardo Siegel

Bernd Janssen

Gerda Von Philipsborn

Wolfgang Steglich

Heinz Pohlemann

August Amann

Hubert Giertz

Rolf Kretzschmar

Martin Traut

Karl-Heinz Geiss

Hans-Guenther Hege

Peter Scharwaechter

Johannes Kunze

Hans-Dieter Lenke

Horst Prinzbach

Ulrich Schoellkopf

Reinhard Schwesinger

Ulrich Ohnsorge

Albrecht Friederang

Rolf Lebkuecher

Hans-Heinrich Hausberg

Gerhard Eisen

Philip A Rossy

Norbert Engel

Peter Thieme

A combination of a phenylacetonitrile and a pyridazinone derivative can be used for the treatment of thromboembolic disorders.

Platelet aggregation inhibiting composition

Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

6-(acylaminoaryl)-3(2H)-pyridazinone derivatives, and their use

2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.

2-aryl-3,4-diazabicyclo(4.n.O)alk-2-en-5-ones for the preparation of an

A combination of acetylsalicylic acid and pyridazinone derivatives can be used for the treatment of thromboembolic disorders.

Combination product

Pyridine derivatives of the formula ##STR1## where R.sup.1 to R.sup.4 have the meanings stated in the description, and their preparation. The substances are useful for treating disorders.

Compounds 1 or

Viral diseases are treated by a method in which an effective amount of 1-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)ethan-1-ol (formula I) ##STR1## is administered enterally, parenterally or topically to a patient suffering therefrom.

Treatment of viral diseases

Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion. The compounds are useful for treating disorders.

6-(acylaminoaryl)-3(2H)-pyridazinone derivatives and their use

6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.

6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as

2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R.sup.1 and R.sup.2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones, and compositions for

Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the p-position of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.

Carbamate dihydropyridazinones, their preparation and therapeutic agents

Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

Novel dihydropyridazinones, their preparation and therapeutic agents

6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 3 carbon atoms and R.sup.2, if R.sup.1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or .beta.-haloethyl or, if R.sup.1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R.sup.2 may also be halomethyl or .alpha.-haloethyl if R.sup.1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.

6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones and therapeutic agents

Chirally substituted 2-imidazolin-5-ones and their use as intermediates for the preparation of optically active aminoacids, especially of optically active .alpha.-substituted aminoacids.

Chirally substituted 2-imidazolin-5-ones

The invention relates to 1-acyl-2-imidazolines, processes for their manufacture, and their use as intermediates.

1-Acyl-2-imidazolines and their manufacture

Alkylaminopropanol derivatives of 2-(o-hydroxyphenyl)-pyrrole of the formula (I) ##STR1## where R is hydrogen or is alkyl of 1 to 8 carbon atoms which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbons atoms or cycloalkyl of 3 to 8 carbon atoms in the ring, or is alkenyl or alkynyl of 2 to 8 carbon atoms or is cycloalkyl or cycloalkenyl of 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or monosubstituted or disubstituted by alkyl or 1 to 3 carbon atoms, and their physiologically acceptable acid addition salts, processes for their preparation, and pharmaceutical formulations which contain the said compounds and may be used in the treatment of cardiac and circulatory disorders.

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Ludwigshafen, Germany

Horst Koenig