Lts Lohmann Therapie-systeme Ag

Lts Lohmann Therapie-systeme Gmbh + Co. Kg

Ucb Pharma Gmbh

Horst Dzekan

Michael Horstmann

Wolfgang Laux

Klaus Schumann

Marion Kursawe

Hans-Rainer Hoffmann

Walter Müller

Peter Steinborn

Sandra Wiedersberg

Tobias Jung

Katja Zinndorf

Walter Muller

The invention relates to a transdermal therapeutic system (TTS) which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system incorporates a back layer and an active substance-containing layer that includes at least one peptide and a carrier substance.

Transdermal therapeutic system for the administration of peptides

A process for introducing a plurality of segregated sheet-like administration forms into a dispenser under formation of a multilayered stack for individually dosable removal, with sheet-like tapes wound-up on rolls being present as starting material, utilizes the following steps. In a first step, a number of sheet-like layers of said tapes, which number corresponds to the stack, is simultaneously drawn from a plurality of rolls. In a further step, the individual tapes are united, using guide means, to form a multilayered strand, which in yet another step, is drawn forward to a cutting station where one length of stack is severed at a time, and wherein a length segment of the multilayered strand corresponding to the stack is substantially in the dispenser prior to being severed from a remainder of the multilayered strand by the cutting device.

Method and device for inserting a plurality of individual sheetlike forms of administration in a dispenser by forming a multilayer pile

A process for the production of sheet-like administration forms by way of coating and drying a solvent-containing, spreadable mass on a substrate is characterized in that the drying takes place in a first drying stage at between 30 and 50&deg; C., in a second drying stage at between 35 and 80&deg; C., and in third drying stage at between 25 and 50&deg; C.

Method for producing film-type dosage

This invention relates to a process for the production of a transdermal therapeutic system containing the active substance 17-.beta.-estradiol and optionally further active substances having a laminated structure positioned on a backing layer which is essentially impermeable to active substance and moisture, one or more matrix layers and optionally an adhesive layer, characterized in that at least one of the matrix layers or the adhesive layer contains anhydrous 17-.beta.-estradiol in crystalline form.

Process for the production of a transdermal therapeutic system

A transdermal therapeutic system containing the active substance 17-.beta.-estradiol and optionally further active substances has a laminated structure positioned on a backing layer which is essentially impermeable to active substance and moisture, at least one matrix layer and optionally an adhesive layer. The at least one matrix layer or the adhesive layer contains anhydrous 17-.beta.-estradiol in crystalline form.

Transdermal therapeutic system comprising the active subtance

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Meinborn, Germany

Horst Dzekan