Hoechst Aktiengesellschaft

American Hoechst Corporation

Horst Dornauer

Noel J De Souza

Bansi Lal

Alihussein N Dohadwalla

Bani K Bhattacharya

Sujata Vasudev Bhat

Adolf D'Sa

Larry A Davis

Grover C Helsley

Vijay A Aroskar

Nandkumar K Dadkar

Julius Mascarenhas

Noel John De Souza

Sujata V Bhati

Alihusein N Donadwalla

Balbir S Bajwa

Noel J deSouza

What are disclosed are pyrimido(6,1-a)isoquinolin-4-one compounds useful as hypotensive agents, bronchodilators, and anti-allergenics, intermediates useful in their preparation, and method for making the compounds and intermediates.

Pyrimido(6-1-a)isoquinolin-4-one derivatives

9,10-substituted-2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2H-pyrimido-(6,1 -a)isoquinoline-4-ones and salts thereof having hypotensive and vasodilating properties.

9,10-substituted

What are disclosed are pyrimido (6,1-a)isoquinolin-4-one compounds useful as hypotensive agents, bronchodilators, and anti-allergenics, intermediates useful in their preparation, and methods for making the compounds and intermediates.

Pyrimido (6,1-a)isoquinolin-4-one derivatives

Hypotensively active triazino-(2,1-a)isoquinoline compounds having the ring system ##STR1## and methods of making and using such compounds.

Triazino(2,1-a)isoquinoline derivatives, compositions and their use as

What are disclosed are compounds of the formula ##STR1## wherein, X is oxygen, sulfur, or halogen, useful as intermediates in the preparation of certain pyrimido(6,1-a)isoquinolin-4-ones having pharmaceutical utilities, and methods for making said intermediates.

Processes for the manufacture of pyrimido[6,1-a]isoquinolinones

Novel 2-aryl-1,2-dialkylcycloalkylamines, physiologically tolerable acid addition salts thereof, and a method of preparing the same are described. These compounds are useful as analgesic and diuretic agents.

2-Aryl-1,2-dialkylcycloalkylamines

The invention relates to novel polyoxygenated labdane derivatives and to a process for preparing same. The polyoxygenated labdane derivatives of the invention are characterized by valuable pharmacological properties, for example a hypotensive effect and a positive inotropic activity.

Polyoxygenated labdane derivatives

This invention relates to a pharmacologically effective substance named Coleforsin, to a process for its preparation from plants belonging to the Labiatae family, and to pharmaceutical preparations containing it.

Pharmacologically effective substance from plants belonging to the

Extraction processes are described resulting in the isolation of a pharmacologically active substance from a plant of the Labiatae family. Chemical and physical properties of this compound are given in the specification. Because of its vasodilating and blood pressure lowering effect the compound is useful as a drug for the treatment of hypertension.

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Bombay, India

Horst Dornauer