Membrana Gmbh

3m Innovative Properties Company

Akzo N.v.

Acordis Industrial Fibers Gmbh

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Excorlab Gmbh

Horst-Dieter Lemke

Bodo Von Harten

Frank Wiese

Martin König

Wolfgang Ramlow

Michael Diamantoglou

Rudi Wollbeck

Joachim Jankowski

Walter Zidek

Christoph Zimmerer

Friedrich Hauck

Frank Heuser

Falko Brettschneider

Marieke Rüth

Vera Jankowski

Detlev Krieter

Hans-Wolfgang Spiess

Paul-Philipp Zänker

Peter Blümler

The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 &#x3bc;g per mof fiber surface.

Method for the elimination of leukocytes from blood

A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 &#x3bc;g per mof fiber surface.

Device for removing leukocytes from blood

Membrane module for testing active substances in cells with an interior chamber ( ) which is limited by a lid ( ), a bottom ( ), and a side wall ( ) and a system of first capillary membranes ( ) and a system of second capillary membranes ( ) located therein and possibly additional systems of capillary membranes, whereby the capillary membranes in interior chamber ( ) are arranged in at least one flat layer parallel to bottom ( ) and in interior chamber ( ) in the extracapillary space a cell culture chamber is formed around the capillary membranes, whereby the capillary membranes have a lumen that can be filled with a fluid, are passing with at least one of its ends through the side wall ( ) of interior chamber ( ) and are embedded at this end separated by systems in a casting material ( ) so that interior chamber ( ) is sealed fluid-tight from the outside, and whereby the capillary membranes of each system are in a fluid connection with their lumens with an inlet device ( ) and/or an outlet device ( ), and whereby interior chamber ( ) has a volume between 0.1 and 5 cm .

Membrane module for testing active substances at cells

Dialysis membrane for hemodialysis in the form of membrane films, tubular films, or hollow filaments made of polysaccharide ethers, are characterized by the fact that the polysaccharide ether has a structure shown by the formula ##STR1## in which Cell is the skeleton of the unmodified cellulose molecule or of the chitin molecule, without hydroxyl groups in each case, s is 3 in the unmodified cellulose molecule and 2 in the chitin molecule, and x corresponds to the degree of etherification, which is in the range from 0.08 to (s-0.4).

Dialysis membrane made of polysaccharide ether

Growing community of inventors

Obernburg, Germany

Horst-Dieter Lemke