Bayer Aktiengesellschaft

Horst Boshagen

Jurgen Stoltefuss

Elisabeth Perzborn

Friedel Seuter

Volker-Bernd Fiedler

Siegfried Goldmann

Ulrich Rosentreter

Rainer Gross

Joachim Hutter

Folker Lieb

Martin Bechem

Siegbert Hebisch

Hermann Oediger

Alexander Straub

Matthias Schramm

Gunter Thomas

Gerhard Franckowiak

Howard-Paul Rounding

Ulrich Horlein

Bodo Junge

Horst Meyer

Friedrich Bossert

Ulrich E Muller

Erwin Bischoff

Martin Scheer

Arnold Paessens

Ulrich Niewohner

Friedrich Berschauer

Peter Norman

Anno De Jong

Nigel J Cuthbert

Hilary P Francis

Karl-August Meng, Deceased

Marie G McKenniff

Matthias Schuller

Karl H Buchel

Ingeborg Hammann

Wolfgang Behrenz

Hanns P Muller

Manfred Plempel

Delf Schmidt

Egbert Wehinger

Stanislav Kazda

Wilfried Draber

Ingo Haller

Peter Andrews

Walter Puls

Heinrich Kolling

Tillmann Hassel

Robertson Towart

Gunther Kinast

Franz-Peter Hoever

Rudiger Sitt

Gerd Reinhardt

Hans P Krause

Walter Lorenz

Ernst Truscheit

The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.

Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine

The present invention relates to the use of 3-formyl-1,4-dihydropyridine derivatives as medicaments for the control of cardiovascular diseases, in particular of pathologically changed blood pressure and of cardiac insufficiency, new compounds and a process for their preparation.

Certain 3-formyl-1, 4-dihydropyridines and their pharmaceutical

Intermediate benzothiazolyl- and benzoxazolyl-aldehyde compounds

2-amino-5-cyano-1,4-dihydropyridines, processes for their preparation

2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,

2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines

2-amino-5-cyano-1,4-dihydropyridines, and their use in medicaments

Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,

Quinoline and isoquinoline intermediates

2,6-dialkyl-4-(benzothiazol- or benzoxazol-4-yl-1,4-dihydropyridines

Positive inotropically active 4-quinolyl-dihydropyridines and use thereas

Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,

Antithrombotic substituted cycloalkano(b)dihydroindole- and

Tetrahydro-1-benz-[c,d],indolepropionic acid sulphonamides of the formula ##STR1## can be prepared by reaction of tetrahydro-1-benz-[c,d]-indolesulphonamides with acrylonitrile and subsequent hydrolysis. The new compounds can be employed inhibiting thrombocyte aggregation.

Tetrahydro-1-benz-(C,D)-indolepropionic acid sulphonamides as

A method for treating a viral infection in a human or animal patient comprising administering to such patient an antivirally effective amount of a substituted hydroxypiperidine, namely a 2-hydroxymethylene-3,4,5-trihydroxypiperidine.

Methods for treating viruses in patients by administering

Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,

Antithrombotic substituted cycloalkano(B)dihydroindole- and

Inhibiting platelet aggregation and antagonizing thromboxane A.sub.2 with new 2-halogen-substituted N-indolyethyl-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl having up to 8 carbon atoms, or

2-halogen-substituted N-indolylethyl-sulphonamides and inhibiting

Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen, trifluoromethyl, carboxyl or alkoxycarbonyl, represents a group of the formula --S(O).sub.m R.sup.3, in which R.sup.3 denotes alkyl or aryl, and m denotes one of the numbers 0, 1 or 2, represents a group of the formula ##STR2## in which R.sup.4 and R.sup.5 are identical or different and represent hydrogen, alkyl, aryl, aralkyl or acetyl, represents a group of the formula --OR.sup.6, in which R.sup.6 denotes hydrogen, alkyl, aryl, aralkyl, alkyl-SO.sub.2 --, aryl--SO.sub.2 --, aralkyl--SO.sub.2 -- or trifluoromethyl, or represents alkyl, alkenyl or cycloalkyl, each of which is optionally substituted by carboxyl, alkoxycarbonyl, halogen, hydroxyl, alkoxy, alkylthio or cyano, R.sup.2 represents aryl which is optionally substituted up to 5 times by halogen, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, alkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, alkylthio, hydroxyl, carboxyl, alkoxycarbonyl, phenyl, phenoxy, benzyloxy, benzylthio or a group of the formula ##STR3## in which R.sup.4 and R.sup.5 have the abovementioned meaning, x represents the number 1, 2 or 3, and y represents the number 0 or 1, where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antagonize thromboxane A.sub.2.

Cycloalkano(1,2-B) indole-sulponamides

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Haan, Germany

Horst Boshagen