Zentaris Gmbh

Aeterna Zentaris Gmbh

Æterna Zentaris Gmbh

Zentaris Ivf Gmbh

Horst Bauer

Jurgen Engel

Michael Damm

Werner Sarlikiotis

Thomas Reissmann

J&uuml;rgen Engel

Jürgen Engel

Matthias Rischer

Peter Romeis

Dominique Di Stefano

Gabriele Stach

Waldemar Salonek

Frank Güthlein

Berthold Roessler

Frank Guthlein

Mattias Rischer

The invention relates to pharmaceutical administration forms with sustained release comprising at least one pharmacologically active peptide. The invention also relates to a method for the production thereof, a kit comprising a lyophilised peptide and an aqueous solution of an inorganic salt or acetic acid salt and the use of an aqueous solution of an inorganic or acetic acid salt for producing a pharmaceutical administration form which releases peptides in a continuous manner over a long period of time.

Administration form for pharmaceutically active peptides with sustained release and method for the production thereof

The invention relates to pharmaceutical compositions suitable for parenteral administration comprising, peptides in the form of acetate, gluconate, glucuronate, lactate, citrate, ascorbate, benzoate or phosphate salts in dissolved or dispersed form and at least one of the acids for forming the salts in free acid form.

Pharmaceutical administration form for peptides, process for its preparation, and use

A method for preventing aggregation of an LHRH antagonist in a pharmaceutical composition. The method comprises combining the LHRH antagonist in the form of an acetate, gluconate, glucuronate, lactate, citrate, ascorbate, benzoate or phosphate salt and at least one of the acids for forming the salts in free acid form.

An aqueous injectable soution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.

Injectable solution of an LHRH antagonist

A method for producing peptide salts, including reacting an acid addition salt of a basic starting peptide in the presence of a diluent in a mixed bed ion exchanger, with a mixture of an acid and a basic ion exchanger during the formation of a free basic peptide, and then separating the ion exchanger and then the free basic peptide, with an inorganic or organic acid, and then forming the desired acid addition salt of the peptide, and removing the diluent.

Method for the synthesis of peptide salts, their use and the pharmaceutical preparations, containing peptide salts

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Hersbruck, Germany

Horst Bauer