Mayo Foundation for Medical Education and Research

Regents of the University of Minnesota

Nanyang Technological University

Horng H Chen

John C Burnett, Jr

Robert D Simari

Shuchong Pan

Ondrej Lisy

Subramanian Venkatraman

Lincoln R Potter

Lim Soo Ghim

This document provides methods and materials related to insulin secreting polypeptides. For example, polypeptides having the ability to induce insulin secretion and methods and materials for using use such polypeptides to induce insulin secretion and to treat diabetes are provided.

Insulin secreting polypeptides

This document provides aquaretic and natriuretic polypeptides. For example, this document provides polypeptides having aquaretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have aquaretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing aquaretic and/or natriuretic activities within a mammal.

Methods of treatment using natriuretic polypeptides

This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing diuretic and/or natriuretic activities within a mammal.

Methods of treatment of heart dysfunctions using diuretic and natriuretic polypeptides

Method of treatment of renal dysfunctions with chimeric natriuretic peptides

Chimeric aquaretic and natriuretic polypeptides lacking vasodilatory activity

Materials and methods related to using natriuretic polypeptides to reduce proliferation of smooth muscle cells, and to reduce or prevent restenosis.

Natriuretic polypeptides for reducing restenosis

This document provides natriuretic polypeptide delivery systems. For example, methods and materials related to natriuretic polypeptide delivery systems, methods and materials related to the use of such delivery systems to deliver natriuretic polypeptides to a mammal over a pro-longed period of time (e.g., weeks to months), and methods and materials related to treating heart failure conditions are provided.

Natriuretic polypeptide delivery systems

Natriuretic polypeptides for reducing or preventing restenosis

This document relates to methods and materials involved in preferentially activating natriuretic peptide receptor-C polypeptides. For example, agonists of natriuretic peptide receptor-C polypeptides as well as methods for activating natriuretic peptide receptor-C polypeptides are provided herein.

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Rochester, MN, United States of America

Horng H Chen