Burstein Technologies, Inc.

Nagaoka Co., Ltd.

University of California

Rotaprep, Inc.

Vindur Technologies, Inc.

Other

Universitè Laval

Lamotte Chemical Products Company

National Research Council of Canada

Horacio Kido

James R Norton

Mark Oscar Worthington

Victor M Ortiz

Bruce D Hammock

Marc Madou

Régis Peytavi

Angel Maquieira

Jorma A Virtanen

Teodor Veres

Michel G Bergeron

Emmanuel Roy

Regis Peytavi

Mary Amasia

Ferenc Szurdoki

Jonathan Siegrist

Robert A Gorkin, Iii

Jim V Zoval

James H Coombs

Jonathan P Siegrist

James W Egan, Jr

Jim Norton

Roger Kornberg

Robert A Gorkin

Alexandra Perebikovsky

Adam Roberts

Ehsan Shamloo

The disclosure is directed to a sample preparation apparatus for grinding or homogenizing test samples. More specifically, the disclosure relates to grinding samples using rotational and linear motion. Grinding samples can be accomplished with an apparatus with a slider-crank mechanism that is attached to an oscillating connecting linkage. The amplitude of oscillatory motion can be greater than or equal to a length of a sample processing chamber.

Grinding samples using rotational and linear motion

Disclosed herein are devices, apparatuses, and methods for grinding of samples. A method includes securing a sample vial in a holder attached to a connecting linkage, the sample vial having a grinding media in the sample vial. The method includes rotating a crank that is operatively coupled to a proximal end of the connecting linkage at a proximal pivot point so that the proximal pivot point undergoes rotational motion. The method includes restricting a distal pivot point of the connecting linkage to a linear path, the distal pivot point near a distal end of the connecting linkage. A result being that the sample vial undergoes a combination of rotational and linear motion.

Methods for grinding of samples using a combination of rotational and linear motion

Disclosed herein are devices, apparatuses, and methods for generating a reciprocating motion for the purpose of grinding or homogenizing samples. An apparatus includes a connecting linkage that extends along a longitudinal axis. The apparatus includes a sample vial holder attached to the connecting linkage. The apparatus includes a crank operatively connected to the proximal end of the connecting linkage, the crank configured to impart rotational motion to the proximal end of the connecting linkage. The apparatus includes a sliding carriage operatively connected to the distal end of the connecting linkage, the sliding carriage configured to restrict the distal end of the connecting linkage to a linear path. The apparatus includes a motor operatively connected to the crank to rotate the crank such that the sample vial holder, in use, moves with a combination of rotational and linear motion.

Apparatuses for generating a reciprocating motion for the purpose of grinding of samples

This invention is directed to a sample preparation apparatus for grinding or homogenizing test samples. More specifically, but without restriction to the particular embodiments hereinafter described in accordance with the best mode of practice, this invention relates to a reciprocating apparatus based upon a slider-crank mechanism for grinding or homogenizing of a sample within a sample vial attached to an oscillating connecting linkage that has an amplitude of oscillatory motion equal to or greater than the length of the sample processing chamber.

Apparatus and method for grinding of samples for analysis

An analytical cartridge and a rotary analytical device with which the cartridge cooperates. The cartridge may have a housing, an axis, analysis chambers spaced from and located circumferentially about the axis, and a magnetically movable element located in and movable within each analysis chamber to mix fluid in the analysis chamber. The rotary analytical device may have a housing with a cavity having an axis, an impeller extending into the cavity and rotatable about the axis to receive and rotate the cartridge, a motor to rotate the impeller, at least one magnetic element near the cavity and offset from the axis, a light source in the housing to direct a beam of light into the cavity and through the analysis chamber of the cartridge, and a light sensor to receive light from the analysis chamber.

Liquid analysis cartridge

Methods and devices using a co-radial arrangement of serial siphon structures composed of siphon valves each separated by a capillary valve to save radial space in a fluidic system. Such serial siphon valves allow to sequentially distribute liquids in a fluidic system upon application of successive centripetal accelerations and decelerations applied to a rotary platform.

Serial siphon valves for fluidic or microfluidic devices

A microfluidic system for processing a sample includes a microfluidic CD in the form a rotatable disc, the disc containing a plurality of separate lysis chambers therein. A magnetic lysis blade and lysis beads are disposed in each of the lysis chambers and a plurality of stationary magnets are disposed adjacent to and separate from the microfluidic CD. The stationary magnets are configured to magnetically interact with each of the magnetic lysis blades upon rotation of the microfluidic CD. Each lysis chamber may have its own separate sample inlet port or, alternatively, the lysis chambers may be connected to one another with a single inlet port coupled to one of the lysis chambers. Downstream processing may include nucleic acid amplification using thermoelectric heating as well as detection using a nucleic acid microarray.

Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection

This invention directs to an optical disc assembly configured to receive an analyte which can be detected by a standard optical disc reader or an optical disc reader modified therefrom. The optical disc assembly may preferably be designed so that the optical disc reader can track the disc and detect the analyte concurrently and discriminably. The optical disc assembly contains or encodes optically readable features which are trackable by the optical disc reader and which have encoded speed information enabling the optical disc reader to rotate the optical disc assembly at a determinable speed. The optical disc assembly also includes an analyte section capable of receiving the analyte that can be detected by the optical disc reader.

Optical discs for measuring analytes

A fluidic circuit for receiving a fluid and separating a component of a fluid from the fluid comprises a separation chamber for receiving the fluid, an air chamber in fluid communication with the separation chamber, and a return channel in fluid communication with the separation chamber. In an advantageous embodiment, the fluidic circuit is subjected to a force, such as a centrifugal force, so that substantially all of the component of the fluid is moved to the return channel while substantially all remaining portions of the fluid are moved to the separation chamber.

Fluidic circuits for sample preparation including bio-discs and methods relating thereto

This invention relates to optical discs that preferably include multiple data layers and are configured to receive analytes which can be detected by an optical disc reader. The optical disc reader may be a standard optical disc reader or an optical disc reader modified therefrom. The optical disc may include (1) a first layer including optically readable structures which have encoded tracking information, and speed information enabling an optical disc reader to rotate the optical disc at a speed that is determinable from the speed information; (2) a second layer including optically readable structures; and (3) an analyte section capable of receiving an analyte which can be read by the optical disc reader.

Multiple data layer optical discs for detecting analytes

Growing community of inventors

Niland, CA, United States of America

Horacio Kido