Dyax Corporation

Merck Patent Gmbh

Ares Trading S.a.

Horacio Gabriel Nastri

Robert Charles Ladner

Rene Hoet

Olivier Leger

Kristin L Rookey

Edward Hirsch Cohen

Christel Iffland

Qi An

Hendricus Renerus Jacobus Mattheus Hoogenboom

Mark J Cartwright

Sean D McKenna

Christine Power

Gang Hao

Paul Bradfield

Vanita D Sood

Hendricus R Hoogenboom

Hendricus RJM Hoogenboom

René Hoet

The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.

Anti-PD-L1 antibodies and uses thereof

Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries

The invention relates to monoclonal antibodies against human CXCR5 and to their use in the treatment of autoimmune or inflammatory diseases, as well as cancers.

Monoclonal antibody directed against CXCR5

Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.

Methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins

Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods are disclose. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens are also disclosed.

A library containing a collection of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and that collectively display at least a portion of the family, the displayed peptides, polypeptides or proteins being encoded by DNA sequences containing sequences encoding a heavy chain CDR region is described.

Growing community of inventors

Newton, MA, United States of America

Horacio Gabriel Nastri