The University of Tokyo

Japan Science and Technology Agency

Tokyo Institute of Technology

Toudai Tlo, Ltd.

Kawasaki Institute of Industrial Promotion

Horacio Cabral

Kazunori Kataoka

Nobuhiro Nishiyama

Yutaka Miura

Hiroaki Kinoh

Masaki Sekino

Shigeto Fukushima

Michiaki Kumagai

Akihiro Kishimura

Soichiro Okazaki

Tsuneo Saga

Ichio Aoki

Sabina Quader

Tsukasa Chida

Peng Mi

Daisuke Kokuryo

Sachiko Kaida

Provided is a polymer including a repeating unit (I) represented by Formula (I) and a repeating unit (II) represented by Formula (II) (in the formulae, m represents 1 or 2, L represents a divalent aromatic hydrocarbon group or a divalent aliphatic hydrocarbon group, Rrepresents a hydrogen atom, an aliphatic hydrocarbon group, or an aromatic hydrocarbon group, X represents OR, SR, or NRR, Rrepresents a hydrogen atom, an aliphatic hydrocarbon group, or an aromatic hydrocarbon group, Rand Reach independently represent a hydrogen atom, an aliphatic hydrocarbon group, or an aromatic hydrocarbon group). 

Polymer, method for producing polymer, and drug conjugate

The problem addressed by the present invention is to develop a pharmaceutical having therapeutic efficacy against epirubicin-resistant tumors. The present invention provides a micelle having an anti-cancer agent disposed inside the core of the micelle formed by an epirubicin-conjugated copolymer.

Micelle containing epirubicin-complexed block copolymer and anti-cancer agent, and pharmaceutical composition containing said micelle applicable to treatment of cancer, resistant cancer or metastatic cancer

The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.

Polymer nanoparticle composite and composition for MRI imaging including same

The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood. The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).

Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same

A coordinate complex of diaminocyclohexane platinum (II) with a block copolymer comprising a poly(ethylene glycol) segment and a poly(carboxylic acid) segment is provided. The complex can be effectively used in treatments for tumors, in particular malignant tumors.

Coordination complex of diaminocyclohexaneplatinum(II) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same

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Tokyo, Japan

Horacio Cabral