Chiroscience, Ltd.

Medeva Europe Limited

Eleusis Therapeutics Us, Inc.

Celltech Pharma Europe Limited

Hooshang Shahriari Zavareh

Graham Johnson

David E Nichols

Daniel Rixson

Michael Christopher James Harris

Peter Haddow

Carrie Sheard

Claire Wombwell

Alexander Schwarz

Gerard Andrew Potter

Marianne Langston

Graham Anthony Frampton

The present invention composition features pharmaceutically acceptable salts of psilocin and compositions thereof. The pharmaceutically acceptable salts of psilocin may be used to treat a disease or condition, such as a neurological injury, an inflammatory condition, chronic pain, or a psychological condition, in a subject in need thereof.

Pharmaceutically acceptable salts of psilocin and uses thereof

The present invention pertains to a process for obtaining a single enantiomer, d or l, of threo-methylphenidate, comprising resolution of a mixture of the enantiomers; racemisation of the unwanted enantiomer, to give a mixture of all four stereoisomers; and separation of the erythro stereoisomers, to leave the same mixture of enantiomers for resolution.

Manufacture of single isomer methylphenidate

Single isomer methylphenidate, selected from the d- and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2% by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an O, O&prime;-diaroyltartaric acid as resolving agent.

Single isomer methylphenidate and resolution process

A process for preparing an enantiomerically-enriched form of threo-ritalinic acid, which comprises resolving a mixture of enantiomers of a salt of the acid, said salt being formed with an achiral acid or base, using a chiral resolving agent. The resolved salt can be esterified, to give the therapeutic agent d-threo-methylphenidate.

Resolution of ritalinic acid salt

Resolution of threo-methylphenidate

Process for preparing levobupivacaine and analogues thereof

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Cambridge, United Kingdom

Hooshang Shahriari Zavareh