The Board of the Rubber Research Institute of Malaysia

Universiti Sains Malaysia

Other

University of Hertfordshire

Hoong Yeet Yeang

Mary Jane Cardosa

Hamzah Samsidar

Elumalai Sunderasan

Hamid Sharifah

Shirley Samuel-Verghese

Pappusamy Arokiaraj

Robert J Slater

Heddwyn Jones

Stephen A Boffey

Wan Y Wan Abdul Rahaman

Kay F Cheong

This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitising agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.

Allergenic proteins of natural rubber latex, their production and use in assays

This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitizing agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.

A method of producing a genetically transformed fluid-producing plant comprises:

Method for the production of proteins in plant fluids

Growing community of inventors

Kuala Lumpur, Malaysia

Hoong Yeet Yeang