Proteus Digital Health, Inc.

Otsuka Pharmaceutical Company, Limited

Applied Materials, Inc.

Primus Power Corporation

Coventya Gmbh

Hooman Hafezi

Timothy Robertson

Mark Zdeblick

Benedict Costello

Robert Duck

George M Savage

Aleksandr Pikelny

Patricia Johnson

Raymond H Schmidt

Eric Snyder

Andrew S Thompson

Yashar Behzadi

Jeremy Frank

Olivier K Colliou

David O'Reilly

Robert Azevedo

Zahedeh Hatamkhany

Marc S Kreidler

Lawrence W Arne

Robert C Leichner

Michael Xiaoxuan Yang

Todd Thompson

John Joseph Curley

Jonathan Withrington

Manoocher Birang

Zhi-Wen Sun

Saravjeet Singh

George S Bokisa

Joseph Frederick Behnke

Mark J Zdeblick

Maria Holen

Aron Rosenfeld

Kityee Au-Yeung

Peter Bjeletich

Iliya Pesic

James Hutchison

Fataneh Omidvar

Kenneth Rowberry

Brad Cozad

Andrew Thompson

Angela Strand

Gregory Moon

Nicholas Williams

Jeffrey Berkman

Kosuke Iwai

Anuj Patel

Tariq Haniff

Kevin K Cheng

Kit Yee Au-Yeung

John O Dukovic

Gerardo Jose La O'

Kurt Scheinpflug

Ai Ling Ching

Richard Huang

Joseph Brian Apisdorf

Kevin Cheng

Robert Leichner

Timothy L Robertson

Maria Casillas Holen

Rod Nicholas

Stephen Joseph Carpmail

Kevin Cheung

Benedict James Costello

Oliver Colliou

Improved ingestible event markers are provided. Aspects of the markers may include the presence of a matrix layer that includes a binder and source of an electron acceptor. Alternatively or in addition to the matrix layer, aspects of the markers may include a large surface area electrode having a surface area that exceeds the surface area of the circuitry of the marker. Aspects further include methods of making and using the ingestible event markers.

Enhanced ingestible event indicators and methods for making and using the same

A pharmaceutical product including a housing that defines a cavity, wherein the cavity stores a pharmaceutical material, and wherein the housing comprises a material configured to dissolve based on contact with a fluid, an ingestible device to encode information in a current signature, wherein the ingestible device is positioned within the housing, and a protective material that encompasses the ingestible device. The ingestible device may be attached to a flexible component, wherein the flexible component is configured to releasably secure the ingestible device within the housing.

Ingestible device with pharmaceutical product

An apparatus that includes a partial power source including a first material and a second material, the partial power source configured to generate, upon contact with a conducting medium, a potential difference between the first material and the second material to provide power to a control device, and generate, using the first material and the second material, a current flow within the conducting medium, the current flow including information encoded based on a variable conductance between the first material and the second material.

Pharma-informatics system

Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.

In-body power source having high surface area electrode

Apparatuses for use with a pharmaceutically acceptable carrier. The apparatus can include a partial power source, which in turn includes electrodes or materials that are configured to generate an electrical potential upon contacting or being exposed to an ionic solution. The apparatus can further include a circuit electrically or communicatively coupled to the partial power source. The circuit can generate various types of signals, such as RF signals, when powered by the partial power source. The circuit is stably fittable to the pharmaceutically acceptable carrier. The apparatus can further include a barrier, a protective layer, or a membrane that isolates the electrodes or materials from the ionic solution and is configured to be dissolved by the ionic solution.

Controlled activation ingestible identifier

The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.

Communication system with enhanced partial power source and method of manufacturing same

The present invention discloses multiple approaches to preventing the capsule walls and other material from interfering with the performance of an electronic device once the device is activated by surrounding fluid. In accordance with the teachings of the present invention, a miniature ingestible device (MID) may be created using excipients and films. The MID, in accordance with various aspects of the present invention, will have a coating or laminating surrounding an electronic device and separating and isolating the device from the pharmaceutical product or drug within the capsule once the capsule is ingested as well as from the capsule itself as the capsule walls begin to collapse during the disintegration process.

Miniature ingestible device

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions.

Highly-swellable polymeric films and compositions comprising the same

An ingestible compositions includes a first polymer layer, an adhesive layer associated with the first polymer layer, where the adhesive layer includes an adhesive material and is configured to releasably adhere to the first polymer layer, an alginate layer adhered to the adhesive layer, and a second polymer layer associated with the alginate layer and configured to releasably adhere to the alginate layer. Aspects further include methods of making and using the compositions.

Alginate on adhesive bilayer laminate film

The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.

Communication system with partial power source

A system for administering prescription medications including a composition and a receiver. The composition may include an active agent, an identifier, and a pharmaceutically acceptable carrier. The active agent may include a controlled pharmaceutical. The identifier may include: a partial power source having a first material and a second material configured to generate a voltage in contact with a conductive fluid within a body of a patient, and a signal generation component configured to use at least a portion of the generated voltage to transmit a signal through the body of the patient. The receiver may be positioned near the body of the patient, wherein the receiver is configured to: receive the signal transmitted through the body of the patient, and automatically report the signal for at least one of identification of the controlled pharmaceutical or tracking physical administration of the controlled pharmaceutical to the body of the patient.

Ingestible event markers having high reliability are provided. Aspects of the ingestible event markers include a support, a control circuit, a first electrochemical material, a second electrochemical material and a membrane. In addition, the ingestible event markers may include one or more components that impart high reliability to the ingestible event marker. Further, the ingestible event markers may include an active agent. In some aspects, the active agent, such as a pharmaceutically active agent or a diagnostic agent may be associated with the membrane.

Highly reliable ingestible event markers and methods for using the same

Growing community of inventors

Redwood City, CA, United States of America

Hooman Hafezi