Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Beijing Molecule Science and Technology Co., Ltd.

Peking University

Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.l.a.

Institute of Pharmacology and Toxicology Academy of Military Medical Science P.l.a. China

Institute of Pharmacology and Toxicology Accademy of Military Medical Sciences P.l.a. China

Beijing Molecule Science Technology Co., Ltd.

Hunan Nanxin Pharmaceutical Co., Ltd.

Hongying Liu

Lili Wang

Song Li

Junhai Xiao

Wu Zhong

Zhibing Zheng

Yunde Xie

Xinbo Zhou

Xingzhou Li

Xiaokui Wang

Guoming Zhao

Cheng Xu

Hao Cui

Chengmai Ruan

Cuifang Lin

Ying Wang

Yang Zhang

Wei Chen

Yao Liu

Jing Su

Jing Yan Ma

Liuhong Yun

Dan Jiang

Zhong Wu

Dan Han

Beifen Shen

Dalong Ma

Hui Qi

Jing Ma

Hongxia Wang

Zihe Rao

Aihua Nie

Hongwei Gong

Cuiling Shu

Songcheng Yang

Wuhong Pei

Zhibing Zhen

Yanbo Yang

Hua Guan

Xiaoqian Xu

Enquan Xu

Meina Li

Xinghai Ma

Xiaomei Ling

Dalong MA

The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.

(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof

Provided are piperazinyl pyrimidine derivatives of formula I having CCRantagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR-related diseases. 

Piperazinyl pyrimidine derivatives, preparation method and use thereof

The present invention relates to a thiazine amide derivative and a pharmaceutical use thereof, and particularly to a compound of formula I (in the formula, variables are as described in the specification), a pharmaceutically acceptable salt, solvate or hydrate thereof. The present invention further relates to a method for preparing the compound, a pharmaceutical composition containing the compound, and a method or use thereof for prevention or treatment of neurodegenerative diseases. 

Thiazine amide derivative and pharmaceutical composition and use thereof

(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof

Disclosed are dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof. Specifically, the compounds described herein in general formula (I), or their isomers, pharmaceutically acceptable salts or hydrates are provided, wherein each variable has the meaning as defined in the description. Also provided are a process for preparing the compounds of the general formula (I), the use of the compounds, an isomer thereof, a pharmaceutically acceptable salt thereof or a hydrate thereof as a medicament, in particular as a medicament for the treatment and/or prevention of Hepatitis B.

Dihydropyrimidine compounds and preparation methods, pharmaceutical compositions and uses thereof

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof. Various substituents in the formula (I) are as defined in the specification. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I), the preparation method of compound of formula (I), and the use of the compound for the preparation of a medicament for treating and/or preventing human peroxisome proliferators activated receptor &#x3b4; (hPPAR&#x3b4;)-associated diseases and risk factors. 

Aryl pyrimidine derivatives, preparation methods and pharmaceutical uses thereof

The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

Arene connected polyamine macrocyclic derivatives, preparation methods and pharmaceutical uses thereof

The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV); and to a method for preparing the compounds of formula I, pharmaceutical compositions comprising the compounds of formula I and use of the compounds of formula II in medical field, particularly in the preparation of medicaments for treating and preventing diabetes (in particular type II diabetes), hyperglycemia, X syndrome, hyperinsulinemia, obesity, atherosclerosis and all kinds of diseases modulated by immune system. 

N-substituted thiomorpholine derivatives as the inhibitors of dipeptidyl peptidase IV and the pharmaceutical uses thereof

The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising the compound, the various radicals in the formula I are the same as defined in the claims. The present invention also relates to a process for preparing the compound of formula I and use of said compound in the preparation of a medicament for the treatment of hyperglycemia, dyslipidemia, type II diabetes mellitus including associated diabetic dyslipidemia 

Tyrosine derivatives substituted by N-arylacryloyl as agonists of hPPAR alpha and/or hPPAR gamma

The present invention relates to a compound of formula I, racemates, optically active isomers, or pharmaceutically acceptable salts or solvates thereof, and a pharmaceutical composition comprising the compound, the various radicals in the formula I are the same as defined in the claims. The present invention also relates to a process for preparing the compound of formula I and use of said compound in the preparation of a medicament for the treatment of hyperglycemia, dyslipidemia, type II diabetes mellitus including associated diabetic dyslipidemia. 

Substituted &#x3b1;-piperazinyl phenylpropionic acid derivatives as hPPAR &#x3b1; and/or hPPAR &#x3b3; agonists

This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R, R, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases activity for treating and preventing neurodegenerative diseases and other nerve disorders associated with nerve injuries or other related diseases 

Substituted 6-membered N-heterocyclic compounds and method for their use as neurological regulator

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Beijing, China

Hongying Liu