Tianjin University

Hainan Lingkang Pharmaceutical Co., Ltd

Hongxun Hao

Linggang Tao

Baohong Hou

Ying Bao

Jun Lv

Junbo Gong

Qiuxiang Yin

Chuang Xie

Yongli Wang

Jingkang Wang

Long Li

Fang He

Zhihong Sun

A novel crystalline form is defined by diffraction angle 2&#x3b8;&#xb0; of X-ray powder diffraction pattern and characteristic peak of differential scanning calorimetry (DSC). The novel crystalline form of Cefamandole Nafate is prepared as follows: adding Cefamandole Nafate in solid state to an organic solvent to form a suspension with a concentration of 0.04&#x2dc;0.3 g/ml, stirring the suspension at 40&#x2dc;50&#xb0; C. for a period of time, and then cooling to 5&#x2dc;15&#xb0; C. at certain cooling rate, continuing to stir for a period of time, then suction filtrating the obtained suspension, the resulting filer cake is Cefamandole Nafate as wet product, which is dried to constant weight to provide the novel crystalline form of Cefamandole Nafate as final product.

Crystalline form of cefamandole nafate compound, preparation and preparing method thereof

It discloses Omeprazole Sodium semihydrate and preparation method thereof, wherein every mole of Omeprazole Sodium semihydrate contains 0.5 mole of water, and it has an X-ray diffraction pattern comprising characteristic peaks at diffraction angles 2&#x3b8; of 6.26&#xb0;&#xb1;0.1&#xb0;, 11.10&#xb0;&#xb1;0.1&#xb0;, 12.20&#xb0;&#xb1;0.1&#xb0;, 15.58&#xb0;&#xb1;0.1&#xb0;, 16.02&#xb0;&#xb1;0.1&#xb0;, 17.12&#xb0;&#xb1;0.1&#xb0;, 19.08&#xb0;&#xb1;0.1&#xb0;, 21.00&#xb0;&#xb1;0.1&#xb0;, 22.68&#xb0;&#xb1;0.1&#xb0;, 23.48&#xb0;&#xb1;0.1&#xb0;, 24.08&#xb0;&#xb1;0.1&#xb0;, 26.52&#xb0;&#xb1;0.1&#xb0; and 28.08&#xb0;&#xb1;0.1&#xb0;. A raw material of Omeprazole Sodium hydrate is added into an organic solvent, stirring for 2&#x2dc;9 hours at constant temperature of 25&#x2dc;60&#xb0; C., thereafter Omeprazole Sodium semihydrate is provided after filtrating and drying.

Omeprazole Sodium semihydrate and preparation method thereof

A novel crystalline form of Cefathiamidine compound and its preparation method, characterizing in its X-ray powder diffraction pattern and differential scanning calorimetry thermogram. Dissolving Cefathiamidine compound with a purity of 98% or higher in a solvent at a temperature of 30&#x2dc;45&#xb0; C. to form a solution, whose concentration is controlled within 0.05&#x2dc;0.2 g/mL, and then adding a solventing-out agent to the solution, wherein the amount of the solventing-out agent is 3&#x2dc;5 times (in volume) of that of the solvent; followed by cooling the solution down to 0&#x2dc;10&#xb0; C. at a rate of 0.2&#x2dc;1&#xb0; C./min; continuing to stir for 1&#x2dc;3 hours, and separating the obtained solid-liquid suspension to provide a novel crystalline form of Cefathiamidine compound after drying.

Crystal form of Cefathiamidine compound and preparation method therefor

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Tianjin, China

Hongxun Hao