Gree Electric Appliances, Inc. of Zhuhai

Bluelight Pharmatech Co., Ltd.

Cas Lamvac (guangzhou) Biomedical Technology Co., Ltd.

Hongxing Wang

Ruixing Zhong

Nan Jiang

Caiyun Jiang

Rong Xie

Yuhui Chen

Jianfei Liu

Zhiping Zhang

Xiaoping Chen

Yinzhou Fan

Li Qin

Baoqian Huang

Shuanghong Liang

Xiaoyi Huang

Xueqing Chen

Xiubing Yan

Siting Zhao

Zhenping Huang

Hot-melt extrusion for producing solid solution comprising nanoparticle formulation of decoquinate is disclosed. Aqueous phase comprising the nanoparticles of hot-melt extruding products is homogeneous and stable. Provided is the composition comprising the solid solution of decoquinate and a method of hot-melt extrusion for producing this composition comprising the solid dispersion of decoquinate. Furthermore, provided is the solid solution comprising nanosized decoquinate formulation having improved water solubility and enhanced delivery of decoquinate in digestive system for absorption, increasing bioavailability, and the efficacy against malaria at the liver stage.

Nanoparticle formulations of decoquinate in the form of solid solution

Implants comprising an antimalarial agent such as decoquinate or another therapeutic drug are disclosed. The implants can be in the form of a complex comprising a drug, a lipid or lipids and optionally a polymer carrier. The present invention provides methods for preparing implants wherein the implants comprise decoquinate or another therapeutic drug, and a lipid or lipids such as cholesterol, monoglycerides, or diglycerides, and optionally a small percentage of a biocompatible polymer based on the total implant weight. The implants are useful for releasing a therapeutic drug at a constant level and maintaining a prophylactic or therapeutic level of the drug in a subject, for preventing a malarial infection or treating other diseases or disorders.

Intramuscular depot of decoquinate compositions and method of prophylaxis and treatment thereof

The invention discloses a centrifugal compressor. The centrifugal compressor includes multiple stages of compression units which are communicated in sequence. Each stage of compression unit includes a diffusion cavity () and a diffusion adjustment device, wherein the diffusion adjustment device includes a movable member () configured to change a radial flow area of the diffusion cavity () provided in correspondence thereto, the movable member () being movably provided in an axial direction of the centrifugal compressor. The invention also discloses a centrifugal unit having the centrifugal compressor. The movable member of each stage of compression unit of the centrifugal compressor changes the radial flow area of the diffusion cavity of this stage of compression unit, thereby effectively reducing the possibility of surging.

Centrifugal compressor and centrifugal unit having the same

The invention discloses a centrifugal compressor. The centrifugal compressor comprises: a housing (), provided with a mounting chamber (), a thread section () being provided on a side wall of the mounting chamber (); an adjusting piece (), mounted in the mounting chamber (), the adjusting piece () being provided with threads adapting to the thread section (); a driving piece (), mounted in the mounting chamber () and configured to drive the adjusting piece () to move forwards or backwards along the thread section (); and an adjustable diffuser (), fixedly connected to the adjusting piece (). The invention also discloses a centrifugal water chilling unit having the centrifugal compressor. The centrifugal compressor and the centrifugal water chilling unit can solve the problem that the adjustable diffuser easily inclines and is stuck, thereby greatly improving the reliability of the centrifugal compressor.

Centrifugal compressor and centrifugal water chilling unit

The invention discloses a centrifugal compressor and a water chilling unit having the same. The centrifugal compressor includes an impeller (), a diffuser (), a volute () and an exhaust diffuser pipe (), the diffuser () including a pressurization passage, air flowing through the impeller () entering an inlet of each pressurization passage, the volute () being configured to collect the air pressurized by the diffuser (), the exhaust diffuser pipe being communicated with the volute, and an extending direction of the exhaust diffuser pipe inclining downwards with respect to a horizontal plane. The extending direction of the exhaust diffuser pipe communicated with the volute inclines downwards with respect to the horizontal plane, so that noise and airflow losses of high-temperature and high-pressure air in the exhaust diffuser pipe expelled from the centrifugal compressor due to bending of the pipe can be reduced, and the noise can be effectively reduced.

Centrifugal compressor and water chilling unit having the same

The present invention relates to a hot melt extrusion composition, a process for preparing a hot melt extruded product using the hot melt extrusion composition, a solid dispersion of decoquinate, and pharmaceutical uses of the composition and the solid dispersion of decoquinate. The hot melt extrusion composition comprises 5 to 30% of decoquinate, 60 to 90% of a polymeric carrier and 0 to 10% of a surfactant. The hot melt extrusion composition can be melted into a liquid at a temperature below the melting point of decoquinate to achieve complete mixing, effectively avoiding the possible thermal decomposition of decoquinate and other components of the composition during the hot-melt process, thus retaining their original structures and pharmacodynamic activity. In the solid dispersion of decoquinate according to the present invention, the active pharmaceutical ingredient and the formulation excipients are melted into amorphous material with homogeneity, possessing improved solubility and drug releasing rate as well as enhanced oral bioavailability and efficacy.

Solid dispersion of decoquinate, a preparation process and its application

A regulator assembly, comprising a vaned diffuser, a motor, a driving gear engaged with a driven gear, the driven gear having rectangle-shaped through holes thereon, the rectangle-shaped through holes disposed and extending along an axis of the driven gear, and a regulating mechanism including a regulator, a supporting member, wherein the regulator is sleeved on the supporting member, and wherein the vaned diffuser is fixed on the supporting member, and regulator sliding members fixed to the regulator through the rectangle-shaped through holes of the driven gear, whereby the motor is configured to drive the driving gear to rotate, the driving gear is configured to drive the driven gear to rotate, the driven gear is configured to push the regulator sliding members to move, and the regulator sliding members are configured to drive the regulator to rotate relative to the vaned diffuser, thus driving the regulator to move along its axis.

Regulator assembly and centrifugal compressor

Centrifugal compressor

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Zhuhai, China

Hongxing Wang